Cargando…

PET Imaging of VMAT2 with the Novel Radioligand [(18)F]FE-DTBZ-d4 in Nonhuman Primates: Comparison with [(11)C]DTBZ and [(18)F]FE-DTBZ

[Image: see text] The vesicular monoamine transporter type 2 (VMAT2) is believed to be responsible for the uptake of monoamines into the vesicles of the synaptic terminals. Two VMAT2 radioligands [(11)C]DTBZ and [(18)F]FP-DTBZ have been used to assess the degree of nigrostriatal deficit in Parkinson...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nag, Sangram, Jahan, Mahabuba, Tóth, Miklós, Nakao, Ryuji, Varrone, Andrea, Halldin, Christer
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8678981/ https://www.ncbi.nlm.nih.gov/pubmed/34813272 http://dx.doi.org/10.1021/acschemneuro.1c00651

Ejemplares similares

Decreased defluorination using the novel beta-cell imaging agent [(18)F]FE-DTBZ-d4 in pigs examined by PET
por: Jahan, Mahabuba, et al.
Publicado: (2011)

Diagnostic value of striatal (18)F-FP-DTBZ PET in Parkinson’s disease
por: Liu, Xiu-Lin, et al.
Publicado: (2022)

Corrigendum: Diagnostic value of striatal (18)F-FP-DTBZ PET in Parkinson's disease
por: Liu, Xiu-Lin, et al.
Publicado: (2022)

A Purification Method of (18)F-FP-(+)-DTBZ via Solid-Phase Extraction With Combined Cartridges
por: Dai, Yuyin, et al.
Publicado: (2021)

Quantitative study of (18)F-(+)DTBZ image: comparison of PET template-based and MRI based image analysis
por: Jung Lung, Hsu, et al.
Publicado: (2018)

Cross-sectional and Test-Retest Characterization of PET with [(18)F]FP-(+)-DTBZ for β Cell Mass Estimates in Diabetes
por: Freeby, Matthew J., et al.
Publicado: (2015)

Brain Imaging of Vesicular Monoamine Transporter Type 2 in Healthy Aging Subjects by (18)F-FP-(+)-DTBZ PET
por: Lin, Kun-Ju, et al.
Publicado: (2013)

PET Imaging a MPTP-Induced Mouse Model of Parkinson’s Disease Using the Fluoropropyl-Dihydrotetrabenazine Analog [(18)F]-DTBZ (AV-133)
por: Toomey, James S., et al.
Publicado: (2012)

Simple, Rapid and Reliable Preparation of [(11)C]-(+)-α-DTBZ of High Quality for Routine Applications
por: Zhang, Jinming, et al.
Publicado: (2012)

Synthesis, Biodistribution, and Radiation Dosimetry of a Novel mGluR5 Radioligand: (18)F-AZD9272
por: Nag, Sangram, et al.
Publicado: (2020)

Elucidating the Relationship Between Diabetes Mellitus and Parkinson’s Disease Using (18)F-FP-(+)-DTBZ, a Positron-Emission Tomography Probe for Vesicular Monoamine Transporter 2
por: Kong, Yanyan, et al.
Publicado: (2020)

PET Evaluation of the Novel F-18 Labeled Reversible Radioligand [(18)F]GEH200449 for Detection of Monoamine Oxidase-B in the Non-Human Primate Brain
por: Varnäs, Katarina, et al.
Publicado: (2023)

Characterization of a Novel M4 PAM PET Radioligand [11C]PF06885190 in Nonhuman Primates (NHP)
por: Nag, Sangram, et al.
Publicado: (2023)

[(18)F]FE-PE2I DAT correlates with Parkinson’s disease duration, stage, and rigidity/bradykinesia scores: a PET radioligand validation study
por: Kerstens, Vera S., et al.
Publicado: (2023)

Microsome Mediated in Vitro Metabolism: A Convenient Method for the Preparation of the PET Radioligand Metabolite [(18)F]FE-PE2I-OH for Translational Dopamine Transporter Imaging
por: Schou, Magnus, et al.
Publicado: (2023)

Synthesis and Autoradiography of Novel F-18 Labeled Reversible Radioligands for Detection of Monoamine Oxidase B
por: Nag, Sangram, et al.
Publicado: (2020)

PET imaging of beta-secretase 1 in the human brain: radiation dosimetry, quantification, and test-retest examination of [(18)F]PF-06684511
por: Arakawa, Ryosuke, et al.
Publicado: (2020)

Reliability of dopamine transporter PET measurements with [(18)F]FE-PE2I in patients with Parkinson’s disease
por: Kerstens, Vera S., et al.
Publicado: (2020)

Longitudinal DAT changes measured with [(18)F]FE-PE2I PET in patients with Parkinson’s disease; a validation study
por: Kerstens, V.S., et al.
Publicado: (2023)

Radiation dosimetry of [(18)F]VAT in nonhuman primates
por: Karimi, Morvarid, et al.
Publicado: (2015)

Neurokinin-3 Receptor Binding in Guinea Pig, Monkey, and Human Brain: In Vitro and in Vivo Imaging Using the Novel Radioligand, [(18)F]Lu AF10628
por: Varnäs, Katarina, et al.
Publicado: (2016)

In vivo TSPO imaging in patients with multiple sclerosis: a brain PET study with [(18)F]FEDAA1106
por: Takano, Akihiro, et al.
Publicado: (2013)

Simplified and accessible [(18)F]F‐AraG synthesis procedure for preclinical PET
por: Högnäsbacka, Antonia A., et al.
Publicado: (2022)

PET Imaging of Fatty Acid Amide Hydrolase with [(18)F]DOPP in Nonhuman Primates
por: Rotstein, Benjamin H., et al.
Publicado: (2014)

Evaluation of [(18)F]Favipiravir in Rodents and Nonhuman Primates (NHP) with Positron Emission Tomography
por: Rong, Jian, et al.
Publicado: (2023)

Characterization of [(11)C]Lu AE92686 as a PET radioligand for phosphodiesterase 10A in the nonhuman primate brain
por: Yang, Kai-Chun, et al.
Publicado: (2016)

Venlafaxine ER Blocks the Norepinephrine Transporter in the Brain of Patients with Major Depressive Disorder: a PET Study Using [(18)F]FMeNER-D(2)
por: Arakawa, Ryosuke, et al.
Publicado: (2019)

PET Imaging of Lung Inflammation with [(18)F]FEDAC, a Radioligand for Translocator Protein (18 kDa)
por: Hatori, Akiko, et al.
Publicado: (2012)

Design and Synthesis of an (18)F-Labeled Version of Phenylethyl Orvinol ([(18)F]FE-PEO) for PET-Imaging of Opioid Receptors
por: Marton, János, et al.
Publicado: (2012)

Large Variation in Brain Exposure of Reference CNS Drugs: a PET Study in Nonhuman Primates
por: Schou, Magnus, et al.
Publicado: (2015)

In response to: Anatomy of (18)F-GE180, a failed radioligand for the TSPO protein
por: Albert, Nathalie L., et al.
Publicado: (2020)

Radiation Absorbed Dose to the Basal Ganglia from Dopamine Transporter Radioligand (18)F-FPCIT
por: Robeson, William, et al.
Publicado: (2014)

Toxicity and radiation dosimetry studies of the serotonin transporter radioligand [(18) F]AFM in rats and monkeys
por: Huang, Ya-Yao, et al.
Publicado: (2014)

Discovery and development of brain-penetrant (18)F-labeled radioligands for neuroimaging of the sigma-2 receptors
por: Zhang, Ying, et al.
Publicado: (2022)

The uptake pattern of 18F-sodium fluoride radioligand in brain tissue after cerebral infarction
por: Kim, Jeong-Min, et al.
Publicado: (2022)

Potential for imaging the high-affinity state of the 5-HT(1B) receptor: a comparison of three PET radioligands with differing intrinsic activity
por: Lindberg, Anton, et al.
Publicado: (2019)

Characterization in nonhuman primates of (R)-[(18)F]OF-Me-NB1 and (S)-[(18)F]OF-Me-NB1 for imaging the GluN2B subunits of the NMDA receptor
por: Zheng, MingQiang, et al.
Publicado: (2022)

F.E.
Publicado: (1943)

Fully Automated GMP-Compliant Synthesis of [(18)F]FE-PE2I
por: Bratteby, Klas, et al.
Publicado: (2021)

PET 6-[(18)F]fluoro-L-m-tyrosine Studies of Dopaminergic Function in Human and Nonhuman Primates
por: Eberling, Jamie L., et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_v1hm683rv9dqogjf7efm39hcl6