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A Study on Dermatomyositis and the Relation to Malignancy

The idiopathic inflammatory myopathies (IIM) are a group of heterogeneous systemic diseases which include as main subtypes: polymyositis (PM), dermatomyositis (DM) and inclusion body myositis (IBM). The key feature of IIMs is the muscle weakness, accompanied by a characteristic skin rash in DM patie...

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Autores principales: TUDORANCEA, ANDREEA DANIELA, CIUREA, PAULINA LUCIA, VREJU, ANANU FLORENTIN, TURCU-STIOLICA, ADINA, GOFITA, CRISTINA ELENA, CRIVEANU, CRISTINA, MUSETESCU, ANCA EMANUELA, DINESCU, STEFAN CRISTIAN
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medical University Publishing House Craiova 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8679146/
https://www.ncbi.nlm.nih.gov/pubmed/35003769
http://dx.doi.org/10.12865/CHSJ.47.03.07
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author TUDORANCEA, ANDREEA DANIELA
CIUREA, PAULINA LUCIA
VREJU, ANANU FLORENTIN
TURCU-STIOLICA, ADINA
GOFITA, CRISTINA ELENA
CRIVEANU, CRISTINA
MUSETESCU, ANCA EMANUELA
DINESCU, STEFAN CRISTIAN
author_facet TUDORANCEA, ANDREEA DANIELA
CIUREA, PAULINA LUCIA
VREJU, ANANU FLORENTIN
TURCU-STIOLICA, ADINA
GOFITA, CRISTINA ELENA
CRIVEANU, CRISTINA
MUSETESCU, ANCA EMANUELA
DINESCU, STEFAN CRISTIAN
author_sort TUDORANCEA, ANDREEA DANIELA
collection PubMed
description The idiopathic inflammatory myopathies (IIM) are a group of heterogeneous systemic diseases which include as main subtypes: polymyositis (PM), dermatomyositis (DM) and inclusion body myositis (IBM). The key feature of IIMs is the muscle weakness, accompanied by a characteristic skin rash in DM patients. The overall risk for malignancy in IIM is higher compared to the age-and sex-matched general population. Most epidemiologic studies have included only PM and DM patients and reported consistently higher rates of malignancy in DM. Most common types of cancer in DM are adenocarcinoma of the lung, ovary or gastrointestinal tract, melanoma and non-Hodgkins lymphoma. The highest risk for malignancy is seen in the first year after DM diagnosis. Multiple disease features have been linked to the development of cancer in DM. These include: older age, male sex, skin necrosis, Gottron sign, heliotrope rash, dysphagia, low complement C4, lymphocytosis, poor response to corticosteroids and rapid disease progression. Our study included 23 patients with DM, divided into two groups based on the association of malignancy, in order to compare clinical and demographic features, laboratory markers and analyze characteristic of cancer development.
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spelling pubmed-86791462022-01-06 A Study on Dermatomyositis and the Relation to Malignancy TUDORANCEA, ANDREEA DANIELA CIUREA, PAULINA LUCIA VREJU, ANANU FLORENTIN TURCU-STIOLICA, ADINA GOFITA, CRISTINA ELENA CRIVEANU, CRISTINA MUSETESCU, ANCA EMANUELA DINESCU, STEFAN CRISTIAN Curr Health Sci J Original Paper The idiopathic inflammatory myopathies (IIM) are a group of heterogeneous systemic diseases which include as main subtypes: polymyositis (PM), dermatomyositis (DM) and inclusion body myositis (IBM). The key feature of IIMs is the muscle weakness, accompanied by a characteristic skin rash in DM patients. The overall risk for malignancy in IIM is higher compared to the age-and sex-matched general population. Most epidemiologic studies have included only PM and DM patients and reported consistently higher rates of malignancy in DM. Most common types of cancer in DM are adenocarcinoma of the lung, ovary or gastrointestinal tract, melanoma and non-Hodgkins lymphoma. The highest risk for malignancy is seen in the first year after DM diagnosis. Multiple disease features have been linked to the development of cancer in DM. These include: older age, male sex, skin necrosis, Gottron sign, heliotrope rash, dysphagia, low complement C4, lymphocytosis, poor response to corticosteroids and rapid disease progression. Our study included 23 patients with DM, divided into two groups based on the association of malignancy, in order to compare clinical and demographic features, laboratory markers and analyze characteristic of cancer development. Medical University Publishing House Craiova 2021 2021-09-30 /pmc/articles/PMC8679146/ /pubmed/35003769 http://dx.doi.org/10.12865/CHSJ.47.03.07 Text en Copyright © 2014, Medical University Publishing House Craiova https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open-access article distributed under the terms of a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License, which permits unrestricted use, adaptation, distribution and reproduction in any medium, non-commercially, provided the new creations are licensed under identical terms as the original work and the original work is properly cited.
spellingShingle Original Paper
TUDORANCEA, ANDREEA DANIELA
CIUREA, PAULINA LUCIA
VREJU, ANANU FLORENTIN
TURCU-STIOLICA, ADINA
GOFITA, CRISTINA ELENA
CRIVEANU, CRISTINA
MUSETESCU, ANCA EMANUELA
DINESCU, STEFAN CRISTIAN
A Study on Dermatomyositis and the Relation to Malignancy
title A Study on Dermatomyositis and the Relation to Malignancy
title_full A Study on Dermatomyositis and the Relation to Malignancy
title_fullStr A Study on Dermatomyositis and the Relation to Malignancy
title_full_unstemmed A Study on Dermatomyositis and the Relation to Malignancy
title_short A Study on Dermatomyositis and the Relation to Malignancy
title_sort study on dermatomyositis and the relation to malignancy
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8679146/
https://www.ncbi.nlm.nih.gov/pubmed/35003769
http://dx.doi.org/10.12865/CHSJ.47.03.07
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