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Correlation of Clinicopathological Features of Breast Cancer with Molecular Subtypes Taking Ki-67 into Consideration: Single Institution Experience Over 5 Years
Background. Molecular classification of breast cancer is commonly done to determine response to therapy and cancer prognosis. Aim of the study was to compare prevalence of molecular subtypes of breast cancer in our institute using immunohistochemistry, including Ki-67, and correlate it with clinical...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medical University Publishing House Craiova
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8679147/ https://www.ncbi.nlm.nih.gov/pubmed/35003765 http://dx.doi.org/10.12865/CHSJ.47.03.03 |
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author | PEREIRA, CHIRAG MARTIS, MANOHAR D'SOUZA, ROHAN TAURO, LEO FRANCIS |
author_facet | PEREIRA, CHIRAG MARTIS, MANOHAR D'SOUZA, ROHAN TAURO, LEO FRANCIS |
author_sort | PEREIRA, CHIRAG |
collection | PubMed |
description | Background. Molecular classification of breast cancer is commonly done to determine response to therapy and cancer prognosis. Aim of the study was to compare prevalence of molecular subtypes of breast cancer in our institute using immunohistochemistry, including Ki-67, and correlate it with clinical and pathological prognostic factors. Results. 300 cases of invasive breast cancer were included in the study. Average age at time of diagnosis was 44 years and average size of tumor was 3.4cms. Invasive ductal carcinoma was the most common histological type (75.3%). The most common molecular subtype was triple negative (34.3%) followed by Luminal B (33.4%), luminal A (17%) and Her-2 positive (15.3%). Large size and poorly differentiated tumors were predominantly triple negative tumors while lymph node metastasis was most commonly seen in Her-2 positive tumors. Conclusion. Molecular subtype of breast carcinoma should routinely be done for all cases of carcinoma breast as it allows to identify aggressive tumors and target therapy accordingly. |
format | Online Article Text |
id | pubmed-8679147 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Medical University Publishing House Craiova |
record_format | MEDLINE/PubMed |
spelling | pubmed-86791472022-01-06 Correlation of Clinicopathological Features of Breast Cancer with Molecular Subtypes Taking Ki-67 into Consideration: Single Institution Experience Over 5 Years PEREIRA, CHIRAG MARTIS, MANOHAR D'SOUZA, ROHAN TAURO, LEO FRANCIS Curr Health Sci J Original Paper Background. Molecular classification of breast cancer is commonly done to determine response to therapy and cancer prognosis. Aim of the study was to compare prevalence of molecular subtypes of breast cancer in our institute using immunohistochemistry, including Ki-67, and correlate it with clinical and pathological prognostic factors. Results. 300 cases of invasive breast cancer were included in the study. Average age at time of diagnosis was 44 years and average size of tumor was 3.4cms. Invasive ductal carcinoma was the most common histological type (75.3%). The most common molecular subtype was triple negative (34.3%) followed by Luminal B (33.4%), luminal A (17%) and Her-2 positive (15.3%). Large size and poorly differentiated tumors were predominantly triple negative tumors while lymph node metastasis was most commonly seen in Her-2 positive tumors. Conclusion. Molecular subtype of breast carcinoma should routinely be done for all cases of carcinoma breast as it allows to identify aggressive tumors and target therapy accordingly. Medical University Publishing House Craiova 2021 2021-09-30 /pmc/articles/PMC8679147/ /pubmed/35003765 http://dx.doi.org/10.12865/CHSJ.47.03.03 Text en Copyright © 2014, Medical University Publishing House Craiova https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open-access article distributed under the terms of a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License, which permits unrestricted use, adaptation, distribution and reproduction in any medium, non-commercially, provided the new creations are licensed under identical terms as the original work and the original work is properly cited. |
spellingShingle | Original Paper PEREIRA, CHIRAG MARTIS, MANOHAR D'SOUZA, ROHAN TAURO, LEO FRANCIS Correlation of Clinicopathological Features of Breast Cancer with Molecular Subtypes Taking Ki-67 into Consideration: Single Institution Experience Over 5 Years |
title | Correlation of Clinicopathological Features of Breast Cancer with Molecular Subtypes Taking Ki-67 into Consideration: Single Institution Experience Over 5 Years |
title_full | Correlation of Clinicopathological Features of Breast Cancer with Molecular Subtypes Taking Ki-67 into Consideration: Single Institution Experience Over 5 Years |
title_fullStr | Correlation of Clinicopathological Features of Breast Cancer with Molecular Subtypes Taking Ki-67 into Consideration: Single Institution Experience Over 5 Years |
title_full_unstemmed | Correlation of Clinicopathological Features of Breast Cancer with Molecular Subtypes Taking Ki-67 into Consideration: Single Institution Experience Over 5 Years |
title_short | Correlation of Clinicopathological Features of Breast Cancer with Molecular Subtypes Taking Ki-67 into Consideration: Single Institution Experience Over 5 Years |
title_sort | correlation of clinicopathological features of breast cancer with molecular subtypes taking ki-67 into consideration: single institution experience over 5 years |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8679147/ https://www.ncbi.nlm.nih.gov/pubmed/35003765 http://dx.doi.org/10.12865/CHSJ.47.03.03 |
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