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Assessing Lifespan and Aging Phenotypes Resulting From FOXO3 Induction Using Mouse Models

Environmental signals, including caloric restriction and oxidative stress, trigger FoxO3 to upregulate genes involved in stress resistance, metabolism, cell cycle arrest, and apoptosis that may help mitigate age-related diseases. Activation of FoxO3 has been shown to have a profound life-extending e...

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Detalles Bibliográficos
Autores principales: Owens, Jesse, Hew, Brian, Tran, Christopher, Xie, Kristal, Willcox, Bradley
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8679280/
http://dx.doi.org/10.1093/geroni/igab046.1417