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Preclinical Characterization of the Radioimmunoconjugate (111)In or (90)Y-FF-21101 Against a P-Cadherin–Expressing Tumor in a Mouse Xenograft Model and a Nonhuman Primate

P-cadherin is overexpressed in various cancers and can be a target for radioimmunotherapy. We investigated the preclinical pharmacokinetics and pharmacology of FF-21101, an (111)In- or (90)Y-conjugated monoclonal antibody against P-cadherin, to evaluate its clinical applications. Methods: The radioc...

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Detalles Bibliográficos
Autores principales:	Funase, Yuichi, Nakamura, Eri, Kajita, Masamichi, Saito, Yasutaka, Oshikiri, Shinobu, Kitano, Michi, Tokura, Masahiko, Hino, Akihiro, Uehara, Tomoya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Society of Nuclear Medicine 2021
Materias:	Theranostics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8679590/ https://www.ncbi.nlm.nih.gov/pubmed/32737245 http://dx.doi.org/10.2967/jnumed.120.245837

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