Failures in thymus medulla regeneration during immune recovery cause tolerance loss and prime recipients for auto-GVHD

Bone marrow transplantation (BMT) is a widely used therapy for blood cancers and primary immunodeficiency. Following transplant, the thymus plays a key role in immune reconstitution by generating a naive αβT cell pool from transplant-derived progenitors. While donor-derived thymopoiesis during the e...

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Detalles Bibliográficos
Autores principales: Alawam, Abdullah S., Cosway, Emilie J., James, Kieran D., Lucas, Beth, Bacon, Andrea, Parnell, Sonia M., White, Andrea J., Jenkinson, William E., Anderson, Graham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8679781/
https://www.ncbi.nlm.nih.gov/pubmed/34910105
http://dx.doi.org/10.1084/jem.20211239

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8679781/
https://www.ncbi.nlm.nih.gov/pubmed/34910105
http://dx.doi.org/10.1084/jem.20211239

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