A high-throughput genome-wide RNAi screen identifies modifiers of survival motor neuron protein

Spinal muscular atrophy (SMA) is a debilitating neurological disorder marked by degeneration of spinal motor neurons and muscle atrophy. SMA results from mutations in survival motor neuron 1 (SMN1), leading to deficiency of survival motor neuron (SMN) protein. Current therapies increase SMN protein...

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Detalles Bibliográficos
Autores principales: McCormack, Nikki M., Abera, Mahlet B., Arnold, Eveline S., Gibbs, Rebecca M., Martin, Scott E., Buehler, Eugen, Chen, Yu-Chi, Chen, Lu, Fischbeck, Kenneth H., Burnett, Barrington G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8679797/
https://www.ncbi.nlm.nih.gov/pubmed/33979606
http://dx.doi.org/10.1016/j.celrep.2021.109125

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