Neutrophil DREAM come true: The not-so-impossible quest for mechanisms of neutrophil function and heterogeneity

Neutrophil functions and responses are heterogeneous, and the nature and categorization of this heterogeneity is achieving considerable interest. Work by Li et al. in this issue of JEM (2021. J. Exp. Med. https://doi.org/10.1084/jem.20211083) identifies how a transcriptional repressor, DREAM, regula...

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Detalles Bibliográficos
Autores principales: Gomez, John C., Doerschuk, Claire M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Insights
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8679798/
https://www.ncbi.nlm.nih.gov/pubmed/34910084
http://dx.doi.org/10.1084/jem.20212141
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author Gomez, John C.
Doerschuk, Claire M.
author_facet Gomez, John C.
Doerschuk, Claire M.
author_sort Gomez, John C.
collection PubMed
description Neutrophil functions and responses are heterogeneous, and the nature and categorization of this heterogeneity is achieving considerable interest. Work by Li et al. in this issue of JEM (2021. J. Exp. Med. https://doi.org/10.1084/jem.20211083) identifies how a transcriptional repressor, DREAM, regulates adhesion of neutrophils to endothelial cells and their transmigration into tissue. This study offers a mechanism for heterogeneity in this critical response of neutrophils to inflammatory stimuli.
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spelling pubmed-86797982022-07-03 Neutrophil DREAM come true: The not-so-impossible quest for mechanisms of neutrophil function and heterogeneity Gomez, John C. Doerschuk, Claire M. J Exp Med Insights Neutrophil functions and responses are heterogeneous, and the nature and categorization of this heterogeneity is achieving considerable interest. Work by Li et al. in this issue of JEM (2021. J. Exp. Med. https://doi.org/10.1084/jem.20211083) identifies how a transcriptional repressor, DREAM, regulates adhesion of neutrophils to endothelial cells and their transmigration into tissue. This study offers a mechanism for heterogeneity in this critical response of neutrophils to inflammatory stimuli. Rockefeller University Press 2021-12-15 /pmc/articles/PMC8679798/ /pubmed/34910084 http://dx.doi.org/10.1084/jem.20212141 Text en © 2021 Gomez and Doerschuk https://creativecommons.org/licenses/by-nc-sa/4.0/http://www.rupress.org/terms/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Insights
Gomez, John C.
Doerschuk, Claire M.
Neutrophil DREAM come true: The not-so-impossible quest for mechanisms of neutrophil function and heterogeneity
title Neutrophil DREAM come true: The not-so-impossible quest for mechanisms of neutrophil function and heterogeneity
title_full Neutrophil DREAM come true: The not-so-impossible quest for mechanisms of neutrophil function and heterogeneity
title_fullStr Neutrophil DREAM come true: The not-so-impossible quest for mechanisms of neutrophil function and heterogeneity
title_full_unstemmed Neutrophil DREAM come true: The not-so-impossible quest for mechanisms of neutrophil function and heterogeneity
title_short Neutrophil DREAM come true: The not-so-impossible quest for mechanisms of neutrophil function and heterogeneity
title_sort neutrophil dream come true: the not-so-impossible quest for mechanisms of neutrophil function and heterogeneity
topic Insights
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8679798/
https://www.ncbi.nlm.nih.gov/pubmed/34910084
http://dx.doi.org/10.1084/jem.20212141
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