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The characteristics and roles of antimicrobial peptides as potential treatment for antibiotic-resistant pathogens: a review

The emergence of antibiotic-resistant bacteria has become a significant and ever-increasing threat to global public health, increasing both morbidity and mortality rates, and the financial burden on health services. Infection by drug-resistant bacteria is anticipated to contribute to the demise of a...

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Autores principales: Zainal Baharin, Nurul Hana, Khairil Mokhtar, Nur Fadhilah, Mohd Desa, Mohd Nasir, Gopalsamy, Banulata, Mohd Zaki, Nor Nadiha, Yuswan, Mohd Hafis, Muthanna, AbdulRahman, Dzaraly, Nurul Diana, Abbasiliasi, Sahar, Mohd Hashim, Amalia, Abdullah Sani, Muhamad Shirwan, Mustafa, Shuhaimi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8679955/
https://www.ncbi.nlm.nih.gov/pubmed/35003909
http://dx.doi.org/10.7717/peerj.12193
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author Zainal Baharin, Nurul Hana
Khairil Mokhtar, Nur Fadhilah
Mohd Desa, Mohd Nasir
Gopalsamy, Banulata
Mohd Zaki, Nor Nadiha
Yuswan, Mohd Hafis
Muthanna, AbdulRahman
Dzaraly, Nurul Diana
Abbasiliasi, Sahar
Mohd Hashim, Amalia
Abdullah Sani, Muhamad Shirwan
Mustafa, Shuhaimi
author_facet Zainal Baharin, Nurul Hana
Khairil Mokhtar, Nur Fadhilah
Mohd Desa, Mohd Nasir
Gopalsamy, Banulata
Mohd Zaki, Nor Nadiha
Yuswan, Mohd Hafis
Muthanna, AbdulRahman
Dzaraly, Nurul Diana
Abbasiliasi, Sahar
Mohd Hashim, Amalia
Abdullah Sani, Muhamad Shirwan
Mustafa, Shuhaimi
author_sort Zainal Baharin, Nurul Hana
collection PubMed
description The emergence of antibiotic-resistant bacteria has become a significant and ever-increasing threat to global public health, increasing both morbidity and mortality rates, and the financial burden on health services. Infection by drug-resistant bacteria is anticipated to contribute to the demise of almost 10 million people by the year 2050 unless a competent and effective response is devised to engage with this issue. The emergence and spread of resistance are commonly caused by the excessive or inappropriate use of antibiotics and substandard pharmaceuticals. It arises when pathogens adapt to different conditions and develop self-defence mechanisms. Currently, novel antimicrobial peptides (AMPs) have been reported to be the sole cure for some clinical cases of infectious diseases such as sepsis and skin infections, although these agents may, on occasion, require administration together with an adjunctive low-dose antibiotic. Although AMPs are a promising alternative form of anti-microbial therapy and easily applied in the medical sector, they still have limitations that should not be taken lightly. Hence, this review explores the characteristics, advantages and disadvantages of AMPs for their potential in treating antibiotic-resistant pathogens.
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spelling pubmed-86799552022-01-06 The characteristics and roles of antimicrobial peptides as potential treatment for antibiotic-resistant pathogens: a review Zainal Baharin, Nurul Hana Khairil Mokhtar, Nur Fadhilah Mohd Desa, Mohd Nasir Gopalsamy, Banulata Mohd Zaki, Nor Nadiha Yuswan, Mohd Hafis Muthanna, AbdulRahman Dzaraly, Nurul Diana Abbasiliasi, Sahar Mohd Hashim, Amalia Abdullah Sani, Muhamad Shirwan Mustafa, Shuhaimi PeerJ Biotechnology The emergence of antibiotic-resistant bacteria has become a significant and ever-increasing threat to global public health, increasing both morbidity and mortality rates, and the financial burden on health services. Infection by drug-resistant bacteria is anticipated to contribute to the demise of almost 10 million people by the year 2050 unless a competent and effective response is devised to engage with this issue. The emergence and spread of resistance are commonly caused by the excessive or inappropriate use of antibiotics and substandard pharmaceuticals. It arises when pathogens adapt to different conditions and develop self-defence mechanisms. Currently, novel antimicrobial peptides (AMPs) have been reported to be the sole cure for some clinical cases of infectious diseases such as sepsis and skin infections, although these agents may, on occasion, require administration together with an adjunctive low-dose antibiotic. Although AMPs are a promising alternative form of anti-microbial therapy and easily applied in the medical sector, they still have limitations that should not be taken lightly. Hence, this review explores the characteristics, advantages and disadvantages of AMPs for their potential in treating antibiotic-resistant pathogens. PeerJ Inc. 2021-12-14 /pmc/articles/PMC8679955/ /pubmed/35003909 http://dx.doi.org/10.7717/peerj.12193 Text en ©2021 Zainal Baharin et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Biotechnology
Zainal Baharin, Nurul Hana
Khairil Mokhtar, Nur Fadhilah
Mohd Desa, Mohd Nasir
Gopalsamy, Banulata
Mohd Zaki, Nor Nadiha
Yuswan, Mohd Hafis
Muthanna, AbdulRahman
Dzaraly, Nurul Diana
Abbasiliasi, Sahar
Mohd Hashim, Amalia
Abdullah Sani, Muhamad Shirwan
Mustafa, Shuhaimi
The characteristics and roles of antimicrobial peptides as potential treatment for antibiotic-resistant pathogens: a review
title The characteristics and roles of antimicrobial peptides as potential treatment for antibiotic-resistant pathogens: a review
title_full The characteristics and roles of antimicrobial peptides as potential treatment for antibiotic-resistant pathogens: a review
title_fullStr The characteristics and roles of antimicrobial peptides as potential treatment for antibiotic-resistant pathogens: a review
title_full_unstemmed The characteristics and roles of antimicrobial peptides as potential treatment for antibiotic-resistant pathogens: a review
title_short The characteristics and roles of antimicrobial peptides as potential treatment for antibiotic-resistant pathogens: a review
title_sort characteristics and roles of antimicrobial peptides as potential treatment for antibiotic-resistant pathogens: a review
topic Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8679955/
https://www.ncbi.nlm.nih.gov/pubmed/35003909
http://dx.doi.org/10.7717/peerj.12193
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