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The characteristics and roles of antimicrobial peptides as potential treatment for antibiotic-resistant pathogens: a review
The emergence of antibiotic-resistant bacteria has become a significant and ever-increasing threat to global public health, increasing both morbidity and mortality rates, and the financial burden on health services. Infection by drug-resistant bacteria is anticipated to contribute to the demise of a...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PeerJ Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8679955/ https://www.ncbi.nlm.nih.gov/pubmed/35003909 http://dx.doi.org/10.7717/peerj.12193 |
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author | Zainal Baharin, Nurul Hana Khairil Mokhtar, Nur Fadhilah Mohd Desa, Mohd Nasir Gopalsamy, Banulata Mohd Zaki, Nor Nadiha Yuswan, Mohd Hafis Muthanna, AbdulRahman Dzaraly, Nurul Diana Abbasiliasi, Sahar Mohd Hashim, Amalia Abdullah Sani, Muhamad Shirwan Mustafa, Shuhaimi |
author_facet | Zainal Baharin, Nurul Hana Khairil Mokhtar, Nur Fadhilah Mohd Desa, Mohd Nasir Gopalsamy, Banulata Mohd Zaki, Nor Nadiha Yuswan, Mohd Hafis Muthanna, AbdulRahman Dzaraly, Nurul Diana Abbasiliasi, Sahar Mohd Hashim, Amalia Abdullah Sani, Muhamad Shirwan Mustafa, Shuhaimi |
author_sort | Zainal Baharin, Nurul Hana |
collection | PubMed |
description | The emergence of antibiotic-resistant bacteria has become a significant and ever-increasing threat to global public health, increasing both morbidity and mortality rates, and the financial burden on health services. Infection by drug-resistant bacteria is anticipated to contribute to the demise of almost 10 million people by the year 2050 unless a competent and effective response is devised to engage with this issue. The emergence and spread of resistance are commonly caused by the excessive or inappropriate use of antibiotics and substandard pharmaceuticals. It arises when pathogens adapt to different conditions and develop self-defence mechanisms. Currently, novel antimicrobial peptides (AMPs) have been reported to be the sole cure for some clinical cases of infectious diseases such as sepsis and skin infections, although these agents may, on occasion, require administration together with an adjunctive low-dose antibiotic. Although AMPs are a promising alternative form of anti-microbial therapy and easily applied in the medical sector, they still have limitations that should not be taken lightly. Hence, this review explores the characteristics, advantages and disadvantages of AMPs for their potential in treating antibiotic-resistant pathogens. |
format | Online Article Text |
id | pubmed-8679955 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | PeerJ Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86799552022-01-06 The characteristics and roles of antimicrobial peptides as potential treatment for antibiotic-resistant pathogens: a review Zainal Baharin, Nurul Hana Khairil Mokhtar, Nur Fadhilah Mohd Desa, Mohd Nasir Gopalsamy, Banulata Mohd Zaki, Nor Nadiha Yuswan, Mohd Hafis Muthanna, AbdulRahman Dzaraly, Nurul Diana Abbasiliasi, Sahar Mohd Hashim, Amalia Abdullah Sani, Muhamad Shirwan Mustafa, Shuhaimi PeerJ Biotechnology The emergence of antibiotic-resistant bacteria has become a significant and ever-increasing threat to global public health, increasing both morbidity and mortality rates, and the financial burden on health services. Infection by drug-resistant bacteria is anticipated to contribute to the demise of almost 10 million people by the year 2050 unless a competent and effective response is devised to engage with this issue. The emergence and spread of resistance are commonly caused by the excessive or inappropriate use of antibiotics and substandard pharmaceuticals. It arises when pathogens adapt to different conditions and develop self-defence mechanisms. Currently, novel antimicrobial peptides (AMPs) have been reported to be the sole cure for some clinical cases of infectious diseases such as sepsis and skin infections, although these agents may, on occasion, require administration together with an adjunctive low-dose antibiotic. Although AMPs are a promising alternative form of anti-microbial therapy and easily applied in the medical sector, they still have limitations that should not be taken lightly. Hence, this review explores the characteristics, advantages and disadvantages of AMPs for their potential in treating antibiotic-resistant pathogens. PeerJ Inc. 2021-12-14 /pmc/articles/PMC8679955/ /pubmed/35003909 http://dx.doi.org/10.7717/peerj.12193 Text en ©2021 Zainal Baharin et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited. |
spellingShingle | Biotechnology Zainal Baharin, Nurul Hana Khairil Mokhtar, Nur Fadhilah Mohd Desa, Mohd Nasir Gopalsamy, Banulata Mohd Zaki, Nor Nadiha Yuswan, Mohd Hafis Muthanna, AbdulRahman Dzaraly, Nurul Diana Abbasiliasi, Sahar Mohd Hashim, Amalia Abdullah Sani, Muhamad Shirwan Mustafa, Shuhaimi The characteristics and roles of antimicrobial peptides as potential treatment for antibiotic-resistant pathogens: a review |
title | The characteristics and roles of antimicrobial peptides as potential treatment for antibiotic-resistant pathogens: a review |
title_full | The characteristics and roles of antimicrobial peptides as potential treatment for antibiotic-resistant pathogens: a review |
title_fullStr | The characteristics and roles of antimicrobial peptides as potential treatment for antibiotic-resistant pathogens: a review |
title_full_unstemmed | The characteristics and roles of antimicrobial peptides as potential treatment for antibiotic-resistant pathogens: a review |
title_short | The characteristics and roles of antimicrobial peptides as potential treatment for antibiotic-resistant pathogens: a review |
title_sort | characteristics and roles of antimicrobial peptides as potential treatment for antibiotic-resistant pathogens: a review |
topic | Biotechnology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8679955/ https://www.ncbi.nlm.nih.gov/pubmed/35003909 http://dx.doi.org/10.7717/peerj.12193 |
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