A New Series of 1,3,4-Oxadiazole Linked Quinolinyl-Pyrazole/Isoxazole Derivatives: Synthesis and Biological Activity Evaluation

A series of 1,3,4-oxadiazole bridged pyrazole/isoxazole bearing quinoline derivatives has been designed and synthesized by a clean and convenient method. Structures of the newly synthesized compounds have been confirmed by FTIR, (1)H and (13)C NMR, and HRMS spectral data. The titled compounds have b...

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Autores principales: Basavanna, V., Chandramouli, M., Kempaiah, C., Bhadraiah, U. K., Chandra, Lingegowda, N. S., Doddamani, Shridevi, Ningaiah, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pleiades Publishing 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8680057/
https://www.ncbi.nlm.nih.gov/pubmed/34934304
http://dx.doi.org/10.1134/S1070363221110128
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author Basavanna, V.
Chandramouli, M.
Kempaiah, C.
Bhadraiah, U. K.
Chandra
Lingegowda, N. S.
Doddamani, Shridevi
Ningaiah, S.
author_facet Basavanna, V.
Chandramouli, M.
Kempaiah, C.
Bhadraiah, U. K.
Chandra
Lingegowda, N. S.
Doddamani, Shridevi
Ningaiah, S.
author_sort Basavanna, V.
collection PubMed
description A series of 1,3,4-oxadiazole bridged pyrazole/isoxazole bearing quinoline derivatives has been designed and synthesized by a clean and convenient method. Structures of the newly synthesized compounds have been confirmed by FTIR, (1)H and (13)C NMR, and HRMS spectral data. The titled compounds have been evaluated for their molecular docking guided antimicrobial and anti-inflammatory activity. One of 1,3,4-oxadiazole bridged quinolinyl-pyrazole derivatives has interacted efficiently with E. Coli protein (PDB file: 1KZN), and has been characterized by good antimicrobial activity against the majority of the tested pathogens. Another product has exhibited excellent anti-inflammatory activity.
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spelling pubmed-86800572021-12-17 A New Series of 1,3,4-Oxadiazole Linked Quinolinyl-Pyrazole/Isoxazole Derivatives: Synthesis and Biological Activity Evaluation Basavanna, V. Chandramouli, M. Kempaiah, C. Bhadraiah, U. K. Chandra Lingegowda, N. S. Doddamani, Shridevi Ningaiah, S. Russ J Gen Chem Article A series of 1,3,4-oxadiazole bridged pyrazole/isoxazole bearing quinoline derivatives has been designed and synthesized by a clean and convenient method. Structures of the newly synthesized compounds have been confirmed by FTIR, (1)H and (13)C NMR, and HRMS spectral data. The titled compounds have been evaluated for their molecular docking guided antimicrobial and anti-inflammatory activity. One of 1,3,4-oxadiazole bridged quinolinyl-pyrazole derivatives has interacted efficiently with E. Coli protein (PDB file: 1KZN), and has been characterized by good antimicrobial activity against the majority of the tested pathogens. Another product has exhibited excellent anti-inflammatory activity. Pleiades Publishing 2021-12-17 2021 /pmc/articles/PMC8680057/ /pubmed/34934304 http://dx.doi.org/10.1134/S1070363221110128 Text en © Pleiades Publishing, Ltd. 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Basavanna, V.
Chandramouli, M.
Kempaiah, C.
Bhadraiah, U. K.
Chandra
Lingegowda, N. S.
Doddamani, Shridevi
Ningaiah, S.
A New Series of 1,3,4-Oxadiazole Linked Quinolinyl-Pyrazole/Isoxazole Derivatives: Synthesis and Biological Activity Evaluation
title A New Series of 1,3,4-Oxadiazole Linked Quinolinyl-Pyrazole/Isoxazole Derivatives: Synthesis and Biological Activity Evaluation
title_full A New Series of 1,3,4-Oxadiazole Linked Quinolinyl-Pyrazole/Isoxazole Derivatives: Synthesis and Biological Activity Evaluation
title_fullStr A New Series of 1,3,4-Oxadiazole Linked Quinolinyl-Pyrazole/Isoxazole Derivatives: Synthesis and Biological Activity Evaluation
title_full_unstemmed A New Series of 1,3,4-Oxadiazole Linked Quinolinyl-Pyrazole/Isoxazole Derivatives: Synthesis and Biological Activity Evaluation
title_short A New Series of 1,3,4-Oxadiazole Linked Quinolinyl-Pyrazole/Isoxazole Derivatives: Synthesis and Biological Activity Evaluation
title_sort new series of 1,3,4-oxadiazole linked quinolinyl-pyrazole/isoxazole derivatives: synthesis and biological activity evaluation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8680057/
https://www.ncbi.nlm.nih.gov/pubmed/34934304
http://dx.doi.org/10.1134/S1070363221110128
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