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Relationships Between Salivary Cortisol Slope and Neuropsychiatric Symptoms in Persons Living With Dementia
While a flatter diurnal cortisol slope has been related to poor health outcomes in healthy populations, little is known about this relationship in persons living with dementia (PLWD). The purpose of this study was to examine the association between diurnalcortisol slope and neuropsychiatric symptoms...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8680324/ http://dx.doi.org/10.1093/geroni/igab046.1693 |
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author | Hwang, Yeji Dong, Fanghong Perez, G Adriana Hodgson, Nancy |
author_facet | Hwang, Yeji Dong, Fanghong Perez, G Adriana Hodgson, Nancy |
author_sort | Hwang, Yeji |
collection | PubMed |
description | While a flatter diurnal cortisol slope has been related to poor health outcomes in healthy populations, little is known about this relationship in persons living with dementia (PLWD). The purpose of this study was to examine the association between diurnalcortisol slope and neuropsychiatric symptoms in PLWD. Secondary data analysis was conducted using baseline data from the Healthy Patterns Study (N=168). Diurnal cortisol slope was calculated using the difference between changes in salivary cortisol from 30 minutes after awakening to bedtime. Spearman rho coefficients were used. Flatter cortisol slope was associated with the presence of symptoms of agitation (r=-0.191, p=0.013) and disinhibition (r=-0.168, p=0.03). Steeper cortisol slope was related to a more severe level of anxiety symptoms (r=0.36, p=0.009) and higher frequency of insomnia (r=0.292, p=0.011). We found that cortisol slope was associated with neuropsychiatric symptoms in PLWD. Future research is needed to examine the mechanisms underlying the relationships. |
format | Online Article Text |
id | pubmed-8680324 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-86803242021-12-17 Relationships Between Salivary Cortisol Slope and Neuropsychiatric Symptoms in Persons Living With Dementia Hwang, Yeji Dong, Fanghong Perez, G Adriana Hodgson, Nancy Innov Aging Abstracts While a flatter diurnal cortisol slope has been related to poor health outcomes in healthy populations, little is known about this relationship in persons living with dementia (PLWD). The purpose of this study was to examine the association between diurnalcortisol slope and neuropsychiatric symptoms in PLWD. Secondary data analysis was conducted using baseline data from the Healthy Patterns Study (N=168). Diurnal cortisol slope was calculated using the difference between changes in salivary cortisol from 30 minutes after awakening to bedtime. Spearman rho coefficients were used. Flatter cortisol slope was associated with the presence of symptoms of agitation (r=-0.191, p=0.013) and disinhibition (r=-0.168, p=0.03). Steeper cortisol slope was related to a more severe level of anxiety symptoms (r=0.36, p=0.009) and higher frequency of insomnia (r=0.292, p=0.011). We found that cortisol slope was associated with neuropsychiatric symptoms in PLWD. Future research is needed to examine the mechanisms underlying the relationships. Oxford University Press 2021-12-17 /pmc/articles/PMC8680324/ http://dx.doi.org/10.1093/geroni/igab046.1693 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of The Gerontological Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Abstracts Hwang, Yeji Dong, Fanghong Perez, G Adriana Hodgson, Nancy Relationships Between Salivary Cortisol Slope and Neuropsychiatric Symptoms in Persons Living With Dementia |
title | Relationships Between Salivary Cortisol Slope and Neuropsychiatric Symptoms in Persons Living With Dementia |
title_full | Relationships Between Salivary Cortisol Slope and Neuropsychiatric Symptoms in Persons Living With Dementia |
title_fullStr | Relationships Between Salivary Cortisol Slope and Neuropsychiatric Symptoms in Persons Living With Dementia |
title_full_unstemmed | Relationships Between Salivary Cortisol Slope and Neuropsychiatric Symptoms in Persons Living With Dementia |
title_short | Relationships Between Salivary Cortisol Slope and Neuropsychiatric Symptoms in Persons Living With Dementia |
title_sort | relationships between salivary cortisol slope and neuropsychiatric symptoms in persons living with dementia |
topic | Abstracts |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8680324/ http://dx.doi.org/10.1093/geroni/igab046.1693 |
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