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Preexisting Comorbidities Predicting COVID-19 and Mortality in the UK Biobank Community Cohort
Hospitalized COVID-19 patients tend to be older and frequently have hypertension, diabetes or CHD, but whether these co-morbidities are more common than in the general older population is unclear. We estimated associations between pre-existing diagnoses and hospitalized COVID-19 alone or with mortal...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8680342/ http://dx.doi.org/10.1093/geroni/igab046.1329 |
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author | Atkins, Janice Masoli, Jane Delgado, Joao Pilling, Luke Kuo, Chia-Ling Kuchel, George Melzer, David |
author_facet | Atkins, Janice Masoli, Jane Delgado, Joao Pilling, Luke Kuo, Chia-Ling Kuchel, George Melzer, David |
author_sort | Atkins, Janice |
collection | PubMed |
description | Hospitalized COVID-19 patients tend to be older and frequently have hypertension, diabetes or CHD, but whether these co-morbidities are more common than in the general older population is unclear. We estimated associations between pre-existing diagnoses and hospitalized COVID-19 alone or with mortality (during the first COVID-19 outbreak, tests performed between March 16 and April 26, 2020). In 269,070 UK Biobank participants aged 65+, 507 (0.2%) became COVID-19 hospital inpatients, of which 141 (27.8%) died. Common preexisting co-morbidities in hospitalized inpatients were hypertension (59.6%), history of falls/fragility fractures (29.4%), CHD (21.5%), T2 diabetes (19. 9%) and asthma (17.6%). However, in adjusted models, pre-existing diagnoses of dementia, T2 diabetes, COPD, pneumonia, depression, atrial fibrillation and hypertension emerged as independent risk factors for COVID-19 hospitalization, the first five remaining statistically significant for related mortality. There are specific high risk pre-existing co-morbidities for COVID-19 hospitalization and deaths in community based older men and women. |
format | Online Article Text |
id | pubmed-8680342 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-86803422021-12-17 Preexisting Comorbidities Predicting COVID-19 and Mortality in the UK Biobank Community Cohort Atkins, Janice Masoli, Jane Delgado, Joao Pilling, Luke Kuo, Chia-Ling Kuchel, George Melzer, David Innov Aging Abstracts Hospitalized COVID-19 patients tend to be older and frequently have hypertension, diabetes or CHD, but whether these co-morbidities are more common than in the general older population is unclear. We estimated associations between pre-existing diagnoses and hospitalized COVID-19 alone or with mortality (during the first COVID-19 outbreak, tests performed between March 16 and April 26, 2020). In 269,070 UK Biobank participants aged 65+, 507 (0.2%) became COVID-19 hospital inpatients, of which 141 (27.8%) died. Common preexisting co-morbidities in hospitalized inpatients were hypertension (59.6%), history of falls/fragility fractures (29.4%), CHD (21.5%), T2 diabetes (19. 9%) and asthma (17.6%). However, in adjusted models, pre-existing diagnoses of dementia, T2 diabetes, COPD, pneumonia, depression, atrial fibrillation and hypertension emerged as independent risk factors for COVID-19 hospitalization, the first five remaining statistically significant for related mortality. There are specific high risk pre-existing co-morbidities for COVID-19 hospitalization and deaths in community based older men and women. Oxford University Press 2021-12-17 /pmc/articles/PMC8680342/ http://dx.doi.org/10.1093/geroni/igab046.1329 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of The Gerontological Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Abstracts Atkins, Janice Masoli, Jane Delgado, Joao Pilling, Luke Kuo, Chia-Ling Kuchel, George Melzer, David Preexisting Comorbidities Predicting COVID-19 and Mortality in the UK Biobank Community Cohort |
title | Preexisting Comorbidities Predicting COVID-19 and Mortality in the UK Biobank Community Cohort |
title_full | Preexisting Comorbidities Predicting COVID-19 and Mortality in the UK Biobank Community Cohort |
title_fullStr | Preexisting Comorbidities Predicting COVID-19 and Mortality in the UK Biobank Community Cohort |
title_full_unstemmed | Preexisting Comorbidities Predicting COVID-19 and Mortality in the UK Biobank Community Cohort |
title_short | Preexisting Comorbidities Predicting COVID-19 and Mortality in the UK Biobank Community Cohort |
title_sort | preexisting comorbidities predicting covid-19 and mortality in the uk biobank community cohort |
topic | Abstracts |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8680342/ http://dx.doi.org/10.1093/geroni/igab046.1329 |
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