Analysis of Cell and Molecular Phenotypes of a Highly Replicated Longevity-Associated FOXO3 Variant in Older Adults

Aging demographics in the US, and other industrialized nations, are resulting in rapidly increasing health care costs from age-related diseases. New therapeutic interventions to extend healthspan in older adults requires understanding connections between basic aging biology and human longevity facto...

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Autores principales: Davy, Philip, Chen, Randi, Allsopp, Richard, Willcox, Bradley
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8680384/
http://dx.doi.org/10.1093/geroni/igab046.1418
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author Davy, Philip
Chen, Randi
Allsopp, Richard
Willcox, Bradley
author_facet Davy, Philip
Chen, Randi
Allsopp, Richard
Willcox, Bradley
author_sort Davy, Philip
collection PubMed
description Aging demographics in the US, and other industrialized nations, are resulting in rapidly increasing health care costs from age-related diseases. New therapeutic interventions to extend healthspan in older adults requires understanding connections between basic aging biology and human longevity factors. Using clinical samples from the Kuakini Honolulu Heart Program (HHP) and their Offspring, we are examining potential links between molecular and cellular mechanisms of aging and the longevity associated FOXO3 genotype (carriage of SNP rs2802292 “G” allele). Telomere dynamics in leucocytes (LTL) have shown strong correlation with multiple lifestyle and health factors. We previously demonstrated a significant protective relation between FOXO3 longevity genotype and LTL in a cross-sectional study. Now we are assessing a longitudinal relation, at three time points over 20+ years, in older men. We are also exploring stem cell frequency and differentiation capacity in neurological and peripheral blood samples to assess FOXO3 genotype and human cell dynamics.
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spelling pubmed-86803842021-12-17 Analysis of Cell and Molecular Phenotypes of a Highly Replicated Longevity-Associated FOXO3 Variant in Older Adults Davy, Philip Chen, Randi Allsopp, Richard Willcox, Bradley Innov Aging Abstracts Aging demographics in the US, and other industrialized nations, are resulting in rapidly increasing health care costs from age-related diseases. New therapeutic interventions to extend healthspan in older adults requires understanding connections between basic aging biology and human longevity factors. Using clinical samples from the Kuakini Honolulu Heart Program (HHP) and their Offspring, we are examining potential links between molecular and cellular mechanisms of aging and the longevity associated FOXO3 genotype (carriage of SNP rs2802292 “G” allele). Telomere dynamics in leucocytes (LTL) have shown strong correlation with multiple lifestyle and health factors. We previously demonstrated a significant protective relation between FOXO3 longevity genotype and LTL in a cross-sectional study. Now we are assessing a longitudinal relation, at three time points over 20+ years, in older men. We are also exploring stem cell frequency and differentiation capacity in neurological and peripheral blood samples to assess FOXO3 genotype and human cell dynamics. Oxford University Press 2021-12-17 /pmc/articles/PMC8680384/ http://dx.doi.org/10.1093/geroni/igab046.1418 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of The Gerontological Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstracts
Davy, Philip
Chen, Randi
Allsopp, Richard
Willcox, Bradley
Analysis of Cell and Molecular Phenotypes of a Highly Replicated Longevity-Associated FOXO3 Variant in Older Adults
title Analysis of Cell and Molecular Phenotypes of a Highly Replicated Longevity-Associated FOXO3 Variant in Older Adults
title_full Analysis of Cell and Molecular Phenotypes of a Highly Replicated Longevity-Associated FOXO3 Variant in Older Adults
title_fullStr Analysis of Cell and Molecular Phenotypes of a Highly Replicated Longevity-Associated FOXO3 Variant in Older Adults
title_full_unstemmed Analysis of Cell and Molecular Phenotypes of a Highly Replicated Longevity-Associated FOXO3 Variant in Older Adults
title_short Analysis of Cell and Molecular Phenotypes of a Highly Replicated Longevity-Associated FOXO3 Variant in Older Adults
title_sort analysis of cell and molecular phenotypes of a highly replicated longevity-associated foxo3 variant in older adults
topic Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8680384/
http://dx.doi.org/10.1093/geroni/igab046.1418
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