Aging Predisposes B cells to Malignancy by Activating c-Myc and Perturbing the Genome and Epigenome

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Age is the single major risk factor for human cancer, but naturally occurring cancers are rarely studied in aging models. Like humans, mice spontaneously develop cancer with age, and standard laboratory strains are predisposed for B-cell lymphoma. Here, we uncover how B-cell lymphoma develops as a c...

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Detalles Bibliográficos
Autores principales: Castro, Jose, Barbieri, Alessandro, Paulo, João, Strelkova, Olga, Sedivy, John, Manis, John, Gladyshev, Vadim, Shindyapina, Anastasia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8680730/
http://dx.doi.org/10.1093/geroni/igab046.2147
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