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Effect of Endemic Fluorosis on Cognitive Function of School Children in Alappuzha District, Kerala: A Cross Sectional Study

BACKGROUND: Exposure to high fluoride levels in drinking water can lead to a number of adverse effects in children, including cognitive dysfunction. Despite being endemic for fluorosis, studies on its effect on the cognitive function of children are lacking in Kerala. AIMS: The aim of this study was...

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Autores principales: Prabhakar, Anjana, Abdulkhayarkutty, Kabeer, Cheruvallil, Shaji Velayudhan, Sudhakaran, Prasanth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8680901/
https://www.ncbi.nlm.nih.gov/pubmed/35002129
http://dx.doi.org/10.4103/aian.AIAN_850_20
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author Prabhakar, Anjana
Abdulkhayarkutty, Kabeer
Cheruvallil, Shaji Velayudhan
Sudhakaran, Prasanth
author_facet Prabhakar, Anjana
Abdulkhayarkutty, Kabeer
Cheruvallil, Shaji Velayudhan
Sudhakaran, Prasanth
author_sort Prabhakar, Anjana
collection PubMed
description BACKGROUND: Exposure to high fluoride levels in drinking water can lead to a number of adverse effects in children, including cognitive dysfunction. Despite being endemic for fluorosis, studies on its effect on the cognitive function of children are lacking in Kerala. AIMS: The aim of this study was to compare the cognitive function of school children with fluorosis with that of normal children and to correlate between the severity of dental fluorosis and cognitive function. SETTINGS AND DESIGN: Cross-sectional study, conducted in collaboration with the National Fluorosis Control Programme, among school children in Alappuzha district, Kerala. METHODS: Children aged 8–10 years, studying in 2 lower primary schools in Alappuzha district with confirmed fluorosis were selected, and compared with healthy age- and sex-matched children from the same school. Raven's Standard Progressive Matrices and MISIC digit span subtest were used to assess the cognitive function. STATISTICAL ANALYSIS: Continuous variables were assessed by independent samples t test and categorical variables by Chi-square test. The relationship between severity of dental fluorosis and grade of cognitive impairment was assessed using Spearman's correlation. RESULTS: There were 60 children each in fluorosis and control groups. The mean age of the children was 8.95 ± 0.50. Only 15% of the children with fluorosis scored Grade I and II Raven's SPM grades (Intellectually superior/above the average) versus 30% in the control group. None of the children without fluorosis scored Grade V (intellectually impaired) category versus 20% in the fluorosis group. The mean digit span was significantly higher in the control group. A strong positive correlation between severity of dental fluorosis and Raven's SPM grades was found (Spearman's correlation coefficient = 0.740). CONCLUSIONS: Fluorosis is associated with impaired cognition in children. There is a positive correlation between severity of dental fluorosis and the grade of cognitive impairment.
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spelling pubmed-86809012022-01-06 Effect of Endemic Fluorosis on Cognitive Function of School Children in Alappuzha District, Kerala: A Cross Sectional Study Prabhakar, Anjana Abdulkhayarkutty, Kabeer Cheruvallil, Shaji Velayudhan Sudhakaran, Prasanth Ann Indian Acad Neurol Original Article BACKGROUND: Exposure to high fluoride levels in drinking water can lead to a number of adverse effects in children, including cognitive dysfunction. Despite being endemic for fluorosis, studies on its effect on the cognitive function of children are lacking in Kerala. AIMS: The aim of this study was to compare the cognitive function of school children with fluorosis with that of normal children and to correlate between the severity of dental fluorosis and cognitive function. SETTINGS AND DESIGN: Cross-sectional study, conducted in collaboration with the National Fluorosis Control Programme, among school children in Alappuzha district, Kerala. METHODS: Children aged 8–10 years, studying in 2 lower primary schools in Alappuzha district with confirmed fluorosis were selected, and compared with healthy age- and sex-matched children from the same school. Raven's Standard Progressive Matrices and MISIC digit span subtest were used to assess the cognitive function. STATISTICAL ANALYSIS: Continuous variables were assessed by independent samples t test and categorical variables by Chi-square test. The relationship between severity of dental fluorosis and grade of cognitive impairment was assessed using Spearman's correlation. RESULTS: There were 60 children each in fluorosis and control groups. The mean age of the children was 8.95 ± 0.50. Only 15% of the children with fluorosis scored Grade I and II Raven's SPM grades (Intellectually superior/above the average) versus 30% in the control group. None of the children without fluorosis scored Grade V (intellectually impaired) category versus 20% in the fluorosis group. The mean digit span was significantly higher in the control group. A strong positive correlation between severity of dental fluorosis and Raven's SPM grades was found (Spearman's correlation coefficient = 0.740). CONCLUSIONS: Fluorosis is associated with impaired cognition in children. There is a positive correlation between severity of dental fluorosis and the grade of cognitive impairment. Wolters Kluwer - Medknow 2021 2020-11-06 /pmc/articles/PMC8680901/ /pubmed/35002129 http://dx.doi.org/10.4103/aian.AIAN_850_20 Text en Copyright: © 2006 - 2020 Annals of Indian Academy of Neurology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Prabhakar, Anjana
Abdulkhayarkutty, Kabeer
Cheruvallil, Shaji Velayudhan
Sudhakaran, Prasanth
Effect of Endemic Fluorosis on Cognitive Function of School Children in Alappuzha District, Kerala: A Cross Sectional Study
title Effect of Endemic Fluorosis on Cognitive Function of School Children in Alappuzha District, Kerala: A Cross Sectional Study
title_full Effect of Endemic Fluorosis on Cognitive Function of School Children in Alappuzha District, Kerala: A Cross Sectional Study
title_fullStr Effect of Endemic Fluorosis on Cognitive Function of School Children in Alappuzha District, Kerala: A Cross Sectional Study
title_full_unstemmed Effect of Endemic Fluorosis on Cognitive Function of School Children in Alappuzha District, Kerala: A Cross Sectional Study
title_short Effect of Endemic Fluorosis on Cognitive Function of School Children in Alappuzha District, Kerala: A Cross Sectional Study
title_sort effect of endemic fluorosis on cognitive function of school children in alappuzha district, kerala: a cross sectional study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8680901/
https://www.ncbi.nlm.nih.gov/pubmed/35002129
http://dx.doi.org/10.4103/aian.AIAN_850_20
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