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Comparing Cortical Demyelination in Geriatric Mild Traumatic Brain Injury and Alzheimer’s Disease
Mild traumatic brain injury (mTBI) accelerates the rate of age-associated brain atrophy, whose pattern resembles the cortical neurodegeneration pattern observed in Alzheimer’s disease (AD). Because the ratio R of T1-to-T2-weighted magnetic resonance imaging (MRI) intensities is a surrogate measure o...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8681001/ http://dx.doi.org/10.1093/geroni/igab046.2412 |
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author | Wang, Shania Chowdhury, Nahian Mahoney, Sean Irimia, Andrei |
author_facet | Wang, Shania Chowdhury, Nahian Mahoney, Sean Irimia, Andrei |
author_sort | Wang, Shania |
collection | PubMed |
description | Mild traumatic brain injury (mTBI) accelerates the rate of age-associated brain atrophy, whose pattern resembles the cortical neurodegeneration pattern observed in Alzheimer’s disease (AD). Because the ratio R of T1-to-T2-weighted magnetic resonance imaging (MRI) intensities is a surrogate measure of cortical myelin concentration, mapping and quantifying changes in this ratio can improve our understanding of demyelination after geriatric mTBI and AD. T1- and T2-weighted MRIs were acquired acutely and ~6 months post-injury from 68 healthy controls (HCs, age (years, y): μ = 76 y, σ = 4 y), 19 mTBIs (age μ = 70 y, σ = 5 y), and 33 ADs (age μ = 77, σ = 6). Volumes were co-registered using 3D Slicer’s BRAINSFit module, and T2-constrained segmentations of T1 volumes were obtained using FreeSurfer. R and its time changes were computed at each cortical location. When comparing mTBI and AD patients to HCs, significant differences in R were found across ~10% and ~23% of the cortex, respectively (p < 0.05). When comparing mTBI to AD, the former exhibited significantly less myelin content in the lateral, medial, and ventral temporal lobes (p < 0.05), on the medial aspects of superior parietal lobules and superior frontal gyri (p < 0.05), and in orbital gyri (p < 0.05), whereas AD subjects had less myelin content on lateral aspect of the parietal lobe (p < 0.05). These results highlight demyelination differences in mTBI and AD. Future studies should examine the long-term trajectories to quantify the risk of neurodegenerative disease after mTBI. |
format | Online Article Text |
id | pubmed-8681001 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-86810012021-12-17 Comparing Cortical Demyelination in Geriatric Mild Traumatic Brain Injury and Alzheimer’s Disease Wang, Shania Chowdhury, Nahian Mahoney, Sean Irimia, Andrei Innov Aging Abstracts Mild traumatic brain injury (mTBI) accelerates the rate of age-associated brain atrophy, whose pattern resembles the cortical neurodegeneration pattern observed in Alzheimer’s disease (AD). Because the ratio R of T1-to-T2-weighted magnetic resonance imaging (MRI) intensities is a surrogate measure of cortical myelin concentration, mapping and quantifying changes in this ratio can improve our understanding of demyelination after geriatric mTBI and AD. T1- and T2-weighted MRIs were acquired acutely and ~6 months post-injury from 68 healthy controls (HCs, age (years, y): μ = 76 y, σ = 4 y), 19 mTBIs (age μ = 70 y, σ = 5 y), and 33 ADs (age μ = 77, σ = 6). Volumes were co-registered using 3D Slicer’s BRAINSFit module, and T2-constrained segmentations of T1 volumes were obtained using FreeSurfer. R and its time changes were computed at each cortical location. When comparing mTBI and AD patients to HCs, significant differences in R were found across ~10% and ~23% of the cortex, respectively (p < 0.05). When comparing mTBI to AD, the former exhibited significantly less myelin content in the lateral, medial, and ventral temporal lobes (p < 0.05), on the medial aspects of superior parietal lobules and superior frontal gyri (p < 0.05), and in orbital gyri (p < 0.05), whereas AD subjects had less myelin content on lateral aspect of the parietal lobe (p < 0.05). These results highlight demyelination differences in mTBI and AD. Future studies should examine the long-term trajectories to quantify the risk of neurodegenerative disease after mTBI. Oxford University Press 2021-12-17 /pmc/articles/PMC8681001/ http://dx.doi.org/10.1093/geroni/igab046.2412 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of The Gerontological Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Abstracts Wang, Shania Chowdhury, Nahian Mahoney, Sean Irimia, Andrei Comparing Cortical Demyelination in Geriatric Mild Traumatic Brain Injury and Alzheimer’s Disease |
title | Comparing Cortical Demyelination in Geriatric Mild Traumatic Brain Injury and Alzheimer’s Disease |
title_full | Comparing Cortical Demyelination in Geriatric Mild Traumatic Brain Injury and Alzheimer’s Disease |
title_fullStr | Comparing Cortical Demyelination in Geriatric Mild Traumatic Brain Injury and Alzheimer’s Disease |
title_full_unstemmed | Comparing Cortical Demyelination in Geriatric Mild Traumatic Brain Injury and Alzheimer’s Disease |
title_short | Comparing Cortical Demyelination in Geriatric Mild Traumatic Brain Injury and Alzheimer’s Disease |
title_sort | comparing cortical demyelination in geriatric mild traumatic brain injury and alzheimer’s disease |
topic | Abstracts |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8681001/ http://dx.doi.org/10.1093/geroni/igab046.2412 |
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