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Depletion of the miR-34a “sponge” MALAT1 in aging skeletal muscle: Implications for age-related muscle loss

We have recently shown that increased levels of reactive oxygen species (ROS) in aging skeletal muscle are associated with increased expression of the senescence-associated microRNA miR-34a-5p (miR-34a). The histone deacetylase Sirt1 is a validated target of miR-34a, and miR-34a expression is induce...

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Detalles Bibliográficos
Autores principales:	Ruan, Ling, Hamrick, Mark, Mendhe, Bharati, Isales, Carlos, Hill, William, McGee-Lawrence, Meghan, Fulzele, Sadanand
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Abstracts
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8681052/ http://dx.doi.org/10.1093/geroni/igab046.2568

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