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Effect of Baseline BMI and IL-6 on Gait Speed Response to Caloric Restriction in Older Adults
We examined whether the effect of caloric restriction (CR) on gait speed change in older adults (67.3±5.27 years) varied by BMI and interleukin 6 (IL-6). Data from eight six-month randomized controlled trials were pooled, with 1268 participants randomized to CR (n=710) and non-CR (n=558) conditions....
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8681110/ http://dx.doi.org/10.1093/geroni/igab046.302 |
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author | Hsieh, Katherine Neiberg, Rebecca Beavers, Kristen Beavers, Daniel |
author_facet | Hsieh, Katherine Neiberg, Rebecca Beavers, Kristen Beavers, Daniel |
author_sort | Hsieh, Katherine |
collection | PubMed |
description | We examined whether the effect of caloric restriction (CR) on gait speed change in older adults (67.3±5.27 years) varied by BMI and interleukin 6 (IL-6). Data from eight six-month randomized controlled trials were pooled, with 1268 participants randomized to CR (n=710) and non-CR (n=558) conditions. Baseline BMI/IL-6 subgroups were constructed using BMI≥35 kg/m2 and IL-6>2.5 pg/dL, and participants were jointly classified as high/high (n=395), high/low (n=208), low/high (n=271), or low/low (n=344). Overall treatment effects showed significant improvements in gait speed in CR versus non-CR [mean difference: 0.02 m/s (95% CI: 0.01, 0.04)]; however, CR assignment significantly interacted with BMI/IL-6 subgroup (p=0.03). Greatest gait speed improvement was observed in the high/high CR subgroup [+0.06 m/s (0.03, 0.09)] and appeared to be driven by no gait speed change among the high/high non-CR subgroup. Gait speed response to CR was greatest in older adults with elevated baseline BMI and IL-6. |
format | Online Article Text |
id | pubmed-8681110 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-86811102021-12-17 Effect of Baseline BMI and IL-6 on Gait Speed Response to Caloric Restriction in Older Adults Hsieh, Katherine Neiberg, Rebecca Beavers, Kristen Beavers, Daniel Innov Aging Abstracts We examined whether the effect of caloric restriction (CR) on gait speed change in older adults (67.3±5.27 years) varied by BMI and interleukin 6 (IL-6). Data from eight six-month randomized controlled trials were pooled, with 1268 participants randomized to CR (n=710) and non-CR (n=558) conditions. Baseline BMI/IL-6 subgroups were constructed using BMI≥35 kg/m2 and IL-6>2.5 pg/dL, and participants were jointly classified as high/high (n=395), high/low (n=208), low/high (n=271), or low/low (n=344). Overall treatment effects showed significant improvements in gait speed in CR versus non-CR [mean difference: 0.02 m/s (95% CI: 0.01, 0.04)]; however, CR assignment significantly interacted with BMI/IL-6 subgroup (p=0.03). Greatest gait speed improvement was observed in the high/high CR subgroup [+0.06 m/s (0.03, 0.09)] and appeared to be driven by no gait speed change among the high/high non-CR subgroup. Gait speed response to CR was greatest in older adults with elevated baseline BMI and IL-6. Oxford University Press 2021-12-17 /pmc/articles/PMC8681110/ http://dx.doi.org/10.1093/geroni/igab046.302 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of The Gerontological Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Abstracts Hsieh, Katherine Neiberg, Rebecca Beavers, Kristen Beavers, Daniel Effect of Baseline BMI and IL-6 on Gait Speed Response to Caloric Restriction in Older Adults |
title | Effect of Baseline BMI and IL-6 on Gait Speed Response to Caloric Restriction in Older Adults |
title_full | Effect of Baseline BMI and IL-6 on Gait Speed Response to Caloric Restriction in Older Adults |
title_fullStr | Effect of Baseline BMI and IL-6 on Gait Speed Response to Caloric Restriction in Older Adults |
title_full_unstemmed | Effect of Baseline BMI and IL-6 on Gait Speed Response to Caloric Restriction in Older Adults |
title_short | Effect of Baseline BMI and IL-6 on Gait Speed Response to Caloric Restriction in Older Adults |
title_sort | effect of baseline bmi and il-6 on gait speed response to caloric restriction in older adults |
topic | Abstracts |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8681110/ http://dx.doi.org/10.1093/geroni/igab046.302 |
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