Metformin Preserves Mitochondrial Integrity at Old Age in Male Rats

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Metformin is being deployed in clinical trials to ameliorate aging in older humans who do not have diabetes. In C. elegans, metformin treatment at old ages exacerbated mitochondrial dysfunction, led to respiratory failure, and shortened lifespan. Metformin is a commonly used, well-tolerated treatmen...

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Detalles Bibliográficos
Autores principales: Wanagat, Jonathan, Herbst, Allen, Hoang, Austin, Kim, Chiye, Aiken, Judd, McKenzie, Debbie, Goldwater, Deena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8681313/
http://dx.doi.org/10.1093/geroni/igab046.2571
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