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Higher Serum BDNF Levels are Associated with Lower Risk of Cognitive Decline in Older Adults :The Otassha Study

Introduction: There has been growing interest in the use of circulating levels of brain-derived neurotrophic factor (BDNF) in the blood as a biomarker in the context of patients with Alzheimer’s and other neurodegenerative diseases. Prospective data on cognitive decline in the broad older population...

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Autores principales: Fujiwara, Yoshinori, Ihara, Kazushige, Hachisu, Mitsugu, Suzuki, Hiroyuki, Kawai, Hisashi, Hashizume, Masahiro, Hirano, Hirohiko, Obuchi, Shuichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8681462/
http://dx.doi.org/10.1093/geroni/igab046.2604
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author Fujiwara, Yoshinori
Ihara, Kazushige
Hachisu, Mitsugu
Suzuki, Hiroyuki
Kawai, Hisashi
Hashizume, Masahiro
Hirano, Hirohiko
Obuchi, Shuichi
author_facet Fujiwara, Yoshinori
Ihara, Kazushige
Hachisu, Mitsugu
Suzuki, Hiroyuki
Kawai, Hisashi
Hashizume, Masahiro
Hirano, Hirohiko
Obuchi, Shuichi
author_sort Fujiwara, Yoshinori
collection PubMed
description Introduction: There has been growing interest in the use of circulating levels of brain-derived neurotrophic factor (BDNF) in the blood as a biomarker in the context of patients with Alzheimer’s and other neurodegenerative diseases. Prospective data on cognitive decline in the broad older population, however, remain limited. We assessed the relationship of serum BDNF levels with short-term decline in cognitive functioning of community-dwelling older adults. Methods. Prospective study of 405 adults 65-84 years old without dementia in Tokyo, Japan. The Montreal Cognitive Assessment-Japanese version (MoCA-J) and its subscales were used. Linear regression assessed standardized differences in test score differences between baseline (2011) and follow-up (2013) visits, according to baseline serum BDNF quartiles, with adjustment for baseline demographics, disease indicators, and cognitive scores. Results: Among participants who performed on the MoCA-J at baseline (scores in bottom quartile), cognitive decline was .65 (95% CI: .08 - 1.2; p=.025) standard deviations (SD) more pronounced in those with lowest than highest BDNF levels. Decline in executive function, but not in other subdomains, was also most pronounced in those with lowest baseline serum BDNF levels (difference: .32 SD; 95%CI: .08-.55; p=.007) Conclusion: Lower serum BDNF levels were associated with greater 2-year cognitive decline in community-dwelling older Japanese adults. Decline varied among cognitive subdomains, and baseline cognition. Research seeking to evaluate the added-value of serum BDNF for screening and/or health promotion initiatives involving physical activity, which has been linked to increment in BDNF levels, is warranted.
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spelling pubmed-86814622021-12-17 Higher Serum BDNF Levels are Associated with Lower Risk of Cognitive Decline in Older Adults :The Otassha Study Fujiwara, Yoshinori Ihara, Kazushige Hachisu, Mitsugu Suzuki, Hiroyuki Kawai, Hisashi Hashizume, Masahiro Hirano, Hirohiko Obuchi, Shuichi Innov Aging Abstracts Introduction: There has been growing interest in the use of circulating levels of brain-derived neurotrophic factor (BDNF) in the blood as a biomarker in the context of patients with Alzheimer’s and other neurodegenerative diseases. Prospective data on cognitive decline in the broad older population, however, remain limited. We assessed the relationship of serum BDNF levels with short-term decline in cognitive functioning of community-dwelling older adults. Methods. Prospective study of 405 adults 65-84 years old without dementia in Tokyo, Japan. The Montreal Cognitive Assessment-Japanese version (MoCA-J) and its subscales were used. Linear regression assessed standardized differences in test score differences between baseline (2011) and follow-up (2013) visits, according to baseline serum BDNF quartiles, with adjustment for baseline demographics, disease indicators, and cognitive scores. Results: Among participants who performed on the MoCA-J at baseline (scores in bottom quartile), cognitive decline was .65 (95% CI: .08 - 1.2; p=.025) standard deviations (SD) more pronounced in those with lowest than highest BDNF levels. Decline in executive function, but not in other subdomains, was also most pronounced in those with lowest baseline serum BDNF levels (difference: .32 SD; 95%CI: .08-.55; p=.007) Conclusion: Lower serum BDNF levels were associated with greater 2-year cognitive decline in community-dwelling older Japanese adults. Decline varied among cognitive subdomains, and baseline cognition. Research seeking to evaluate the added-value of serum BDNF for screening and/or health promotion initiatives involving physical activity, which has been linked to increment in BDNF levels, is warranted. Oxford University Press 2021-12-17 /pmc/articles/PMC8681462/ http://dx.doi.org/10.1093/geroni/igab046.2604 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of The Gerontological Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstracts
Fujiwara, Yoshinori
Ihara, Kazushige
Hachisu, Mitsugu
Suzuki, Hiroyuki
Kawai, Hisashi
Hashizume, Masahiro
Hirano, Hirohiko
Obuchi, Shuichi
Higher Serum BDNF Levels are Associated with Lower Risk of Cognitive Decline in Older Adults :The Otassha Study
title Higher Serum BDNF Levels are Associated with Lower Risk of Cognitive Decline in Older Adults :The Otassha Study
title_full Higher Serum BDNF Levels are Associated with Lower Risk of Cognitive Decline in Older Adults :The Otassha Study
title_fullStr Higher Serum BDNF Levels are Associated with Lower Risk of Cognitive Decline in Older Adults :The Otassha Study
title_full_unstemmed Higher Serum BDNF Levels are Associated with Lower Risk of Cognitive Decline in Older Adults :The Otassha Study
title_short Higher Serum BDNF Levels are Associated with Lower Risk of Cognitive Decline in Older Adults :The Otassha Study
title_sort higher serum bdnf levels are associated with lower risk of cognitive decline in older adults :the otassha study
topic Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8681462/
http://dx.doi.org/10.1093/geroni/igab046.2604
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