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Frailty and Processing Speed Performance at the Cusp of Midlife in CATSLife

Frailty is an important multi-domain measure of health status and aging. Processing speed (PS) performance may be predictive of later frailty among older adults, but the interrelation between frailty and PS at the cusp of mid-adulthood is unclear. Using data from the ongoing Colorado Adoption/Twin S...

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Autores principales: Luna, Maria, Pahlen, Shandell, Corley, Robin, Wadsworth, Sally, Reynolds, Chandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8681548/
http://dx.doi.org/10.1093/geroni/igab046.2624
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author Luna, Maria
Pahlen, Shandell
Corley, Robin
Wadsworth, Sally
Reynolds, Chandra
author_facet Luna, Maria
Pahlen, Shandell
Corley, Robin
Wadsworth, Sally
Reynolds, Chandra
author_sort Luna, Maria
collection PubMed
description Frailty is an important multi-domain measure of health status and aging. Processing speed (PS) performance may be predictive of later frailty among older adults, but the interrelation between frailty and PS at the cusp of mid-adulthood is unclear. Using data from the ongoing Colorado Adoption/Twin Study of Lifespan Behavioral Development and Cognitive Aging (CATSLife; N = 1213; Mean age = 33.22 years; SD = 5.0), we constructed a 24-item frailty sum score across anthropomorphic, objective health, and perceived health and engagement measures based on the Accumulation of Deficits model. PS was measured using the Colorado Perceptual Speed (CPS) and WAIS-III Digit Symbol (DS) tests. All mixed-effects regression models accounted for clustering among siblings, and covariates included sex, age, race, ethnicity, and educational attainment. Intraclass correlations (ICCs) [95% CI] for frailty among siblings, adjusted for sex and age, ranged from near zero for siblings in adoptive families, .13 [.08-.30] for nonadoptive siblings/fraternal (DZ) twins, and .44 [.40-.48] for identical (MZ) twins, suggesting possible heritable influences. Poorer PS performance was associated with higher frailty, but was significant for DS only (B: DS = -0.43, p =.005). Furthermore, the DS-frailty association was magnified by age (B: DSxAge = -0.06, p =.025), suggesting that the associations between processing speed and frailty may increase with age. These findings help elucidate the interrelationship between indicators of frailty and cognitive performance for adults approaching midlife, a salient and understudied period within lifespan development.
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spelling pubmed-86815482021-12-17 Frailty and Processing Speed Performance at the Cusp of Midlife in CATSLife Luna, Maria Pahlen, Shandell Corley, Robin Wadsworth, Sally Reynolds, Chandra Innov Aging Abstracts Frailty is an important multi-domain measure of health status and aging. Processing speed (PS) performance may be predictive of later frailty among older adults, but the interrelation between frailty and PS at the cusp of mid-adulthood is unclear. Using data from the ongoing Colorado Adoption/Twin Study of Lifespan Behavioral Development and Cognitive Aging (CATSLife; N = 1213; Mean age = 33.22 years; SD = 5.0), we constructed a 24-item frailty sum score across anthropomorphic, objective health, and perceived health and engagement measures based on the Accumulation of Deficits model. PS was measured using the Colorado Perceptual Speed (CPS) and WAIS-III Digit Symbol (DS) tests. All mixed-effects regression models accounted for clustering among siblings, and covariates included sex, age, race, ethnicity, and educational attainment. Intraclass correlations (ICCs) [95% CI] for frailty among siblings, adjusted for sex and age, ranged from near zero for siblings in adoptive families, .13 [.08-.30] for nonadoptive siblings/fraternal (DZ) twins, and .44 [.40-.48] for identical (MZ) twins, suggesting possible heritable influences. Poorer PS performance was associated with higher frailty, but was significant for DS only (B: DS = -0.43, p =.005). Furthermore, the DS-frailty association was magnified by age (B: DSxAge = -0.06, p =.025), suggesting that the associations between processing speed and frailty may increase with age. These findings help elucidate the interrelationship between indicators of frailty and cognitive performance for adults approaching midlife, a salient and understudied period within lifespan development. Oxford University Press 2021-12-17 /pmc/articles/PMC8681548/ http://dx.doi.org/10.1093/geroni/igab046.2624 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of The Gerontological Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstracts
Luna, Maria
Pahlen, Shandell
Corley, Robin
Wadsworth, Sally
Reynolds, Chandra
Frailty and Processing Speed Performance at the Cusp of Midlife in CATSLife
title Frailty and Processing Speed Performance at the Cusp of Midlife in CATSLife
title_full Frailty and Processing Speed Performance at the Cusp of Midlife in CATSLife
title_fullStr Frailty and Processing Speed Performance at the Cusp of Midlife in CATSLife
title_full_unstemmed Frailty and Processing Speed Performance at the Cusp of Midlife in CATSLife
title_short Frailty and Processing Speed Performance at the Cusp of Midlife in CATSLife
title_sort frailty and processing speed performance at the cusp of midlife in catslife
topic Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8681548/
http://dx.doi.org/10.1093/geroni/igab046.2624
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