Insertion of the protective APP A673T mutation by CRISPR/Cas9 base editing or PRIME editing.

There is currently no treatment for Alzheimer disease (AD). However, the Icelandic mutation in the APP gene (A673T) has been shown to confer a protection against the onset and development of AD (Jonsson et al. Nature 2012). This single nucleotide mutation in APP exon 16 reduces the cleavage of the A...

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Detalles Bibliográficos
Autores principales: Tremblay, Jacques, Guyon, Antoine, Rousseau, Joël, Tremblay, Guillaume, Begin, Francis-Gabriel, Lamothe, Gabriel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8681611/
http://dx.doi.org/10.1093/geroni/igab046.2511

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