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Associations Between Perceived Fatigability and Amyloid Status in the Baltimore Longitudinal Study of Aging

Higher level of and greater longitudinal increase in perceived fatigability are linked to cognitive decline and lower brain volumes in older adults. However, it remains unclear whether perceived fatigability is associated with Alzheimer’s disease-related brain pathology. In the BLSA, 163 participant...

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Autores principales: Liu, Fangyu, Dougherty, Ryan, Wanigatunga, Amal, Bilgel, Murat, An, Yang, Simonsick, Eleanor, Resnick, Susan, Schrack, Jennifer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8682213/
http://dx.doi.org/10.1093/geroni/igab046.799
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author Liu, Fangyu
Dougherty, Ryan
Wanigatunga, Amal
Bilgel, Murat
An, Yang
Simonsick, Eleanor
Resnick, Susan
Schrack, Jennifer
author_facet Liu, Fangyu
Dougherty, Ryan
Wanigatunga, Amal
Bilgel, Murat
An, Yang
Simonsick, Eleanor
Resnick, Susan
Schrack, Jennifer
author_sort Liu, Fangyu
collection PubMed
description Higher level of and greater longitudinal increase in perceived fatigability are linked to cognitive decline and lower brain volumes in older adults. However, it remains unclear whether perceived fatigability is associated with Alzheimer’s disease-related brain pathology. In the BLSA, 163 participants without neurological disease or cognitive impairment (aged 74.7+/-8.4 years, 45% men) were assessed for perceived fatigability using rating of perceived exertion after a 5-minute (0.67 m/s) treadmill walk and Aß burden using 11C-Pittsburgh compound B (PiB) positron emission tomography. Forty-four participants were PiB+ based on a mean cortical distribution volume ratio (DVR) cut point of 1.066. After adjusting for demographics, body composition, comorbidities and ApoE-e4, higher perceived fatigability was not associated with PiB+ status (OR=0.84; 95% CI: 0.69, 1.05). Results suggest perceived fatigability may contribute to cognitive decline through pathways other than Aß pathology. Future studies should target other mechanisms linking perceived fatigability and cognitive decline.
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spelling pubmed-86822132021-12-17 Associations Between Perceived Fatigability and Amyloid Status in the Baltimore Longitudinal Study of Aging Liu, Fangyu Dougherty, Ryan Wanigatunga, Amal Bilgel, Murat An, Yang Simonsick, Eleanor Resnick, Susan Schrack, Jennifer Innov Aging Abstracts Higher level of and greater longitudinal increase in perceived fatigability are linked to cognitive decline and lower brain volumes in older adults. However, it remains unclear whether perceived fatigability is associated with Alzheimer’s disease-related brain pathology. In the BLSA, 163 participants without neurological disease or cognitive impairment (aged 74.7+/-8.4 years, 45% men) were assessed for perceived fatigability using rating of perceived exertion after a 5-minute (0.67 m/s) treadmill walk and Aß burden using 11C-Pittsburgh compound B (PiB) positron emission tomography. Forty-four participants were PiB+ based on a mean cortical distribution volume ratio (DVR) cut point of 1.066. After adjusting for demographics, body composition, comorbidities and ApoE-e4, higher perceived fatigability was not associated with PiB+ status (OR=0.84; 95% CI: 0.69, 1.05). Results suggest perceived fatigability may contribute to cognitive decline through pathways other than Aß pathology. Future studies should target other mechanisms linking perceived fatigability and cognitive decline. Oxford University Press 2021-12-17 /pmc/articles/PMC8682213/ http://dx.doi.org/10.1093/geroni/igab046.799 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of The Gerontological Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstracts
Liu, Fangyu
Dougherty, Ryan
Wanigatunga, Amal
Bilgel, Murat
An, Yang
Simonsick, Eleanor
Resnick, Susan
Schrack, Jennifer
Associations Between Perceived Fatigability and Amyloid Status in the Baltimore Longitudinal Study of Aging
title Associations Between Perceived Fatigability and Amyloid Status in the Baltimore Longitudinal Study of Aging
title_full Associations Between Perceived Fatigability and Amyloid Status in the Baltimore Longitudinal Study of Aging
title_fullStr Associations Between Perceived Fatigability and Amyloid Status in the Baltimore Longitudinal Study of Aging
title_full_unstemmed Associations Between Perceived Fatigability and Amyloid Status in the Baltimore Longitudinal Study of Aging
title_short Associations Between Perceived Fatigability and Amyloid Status in the Baltimore Longitudinal Study of Aging
title_sort associations between perceived fatigability and amyloid status in the baltimore longitudinal study of aging
topic Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8682213/
http://dx.doi.org/10.1093/geroni/igab046.799
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