Pleiotropy of Alzheimer’s Disease and Educational Attainment: Insights from the Summary Statistics

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Epidemiological studies report beneficial associations of higher educational attainment (EDU) with Alzheimer’s disease (AD). Prior genome-wide association studies (GWAS) also reported variants associated with AD and EDU separately. The analysis of pleiotropic predisposition to these phenotypes may s...

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Autores principales: Loika, Yury, Loiko, Elena, Culminskaya, Irina, Kulminski, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8682296/
http://dx.doi.org/10.1093/geroni/igab046.3518
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author Loika, Yury
Loiko, Elena
Culminskaya, Irina
Kulminski, Alexander
author_facet Loika, Yury
Loiko, Elena
Culminskaya, Irina
Kulminski, Alexander
author_sort Loika, Yury
collection PubMed
description Epidemiological studies report beneficial associations of higher educational attainment (EDU) with Alzheimer’s disease (AD). Prior genome-wide association studies (GWAS) also reported variants associated with AD and EDU separately. The analysis of pleiotropic predisposition to these phenotypes may shed light on EDU-related protection against AD. We examined pleiotropic predisposition to AD and EDU using Fisher’s method and omnibus test applied to summary statistics for single nucleotide polymorphisms (SNPs) associated with AD and EDU in large-scale univariate GWAS at suggestive-effect (5×10-8
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spelling pubmed-86822962021-12-20 Pleiotropy of Alzheimer’s Disease and Educational Attainment: Insights from the Summary Statistics Loika, Yury Loiko, Elena Culminskaya, Irina Kulminski, Alexander Innov Aging Abstracts Epidemiological studies report beneficial associations of higher educational attainment (EDU) with Alzheimer’s disease (AD). Prior genome-wide association studies (GWAS) also reported variants associated with AD and EDU separately. The analysis of pleiotropic predisposition to these phenotypes may shed light on EDU-related protection against AD. We examined pleiotropic predisposition to AD and EDU using Fisher’s method and omnibus test applied to summary statistics for single nucleotide polymorphisms (SNPs) associated with AD and EDU in large-scale univariate GWAS at suggestive-effect (5×10-8 Oxford University Press 2021-12-17 /pmc/articles/PMC8682296/ http://dx.doi.org/10.1093/geroni/igab046.3518 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of The Gerontological Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstracts
Loika, Yury
Loiko, Elena
Culminskaya, Irina
Kulminski, Alexander
Pleiotropy of Alzheimer’s Disease and Educational Attainment: Insights from the Summary Statistics
title Pleiotropy of Alzheimer’s Disease and Educational Attainment: Insights from the Summary Statistics
title_full Pleiotropy of Alzheimer’s Disease and Educational Attainment: Insights from the Summary Statistics
title_fullStr Pleiotropy of Alzheimer’s Disease and Educational Attainment: Insights from the Summary Statistics
title_full_unstemmed Pleiotropy of Alzheimer’s Disease and Educational Attainment: Insights from the Summary Statistics
title_short Pleiotropy of Alzheimer’s Disease and Educational Attainment: Insights from the Summary Statistics
title_sort pleiotropy of alzheimer’s disease and educational attainment: insights from the summary statistics
topic Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8682296/
http://dx.doi.org/10.1093/geroni/igab046.3518
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