Cargando…

Pleiotropy of Alzheimer’s Disease and Educational Attainment: Insights from the Summary Statistics

Mostrar otras versiones (1)

Epidemiological studies report beneficial associations of higher educational attainment (EDU) with Alzheimer’s disease (AD). Prior genome-wide association studies (GWAS) also reported variants associated with AD and EDU separately. The analysis of pleiotropic predisposition to these phenotypes may s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Loika, Yury, Loiko, Elena, Culminskaya, Irina, Kulminski, Alexander
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Abstracts
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8682296/ http://dx.doi.org/10.1093/geroni/igab046.3518

Ejemplares similares

Pleiotropy of Alzheimer’s Disease and Educational Attainment: Insights from the Summary Statistics
por: Loika, Yury, et al.
Publicado: (2021)

Pleiotropic predisposition to Alzheimer’s disease and educational attainment: insights from the summary statistics analysis
por: Kulminski, Alexander M., et al.
Publicado: (2021)

EXOME-WIDE STUDY IDENTIFIED 12 PLEIOTROPIC LOCI ASSOCIATED WITH ALZHEIMER’S AND CARDIOVASCULAR DISEASE RISKS
por: Loika, Yury, et al.
Publicado: (2022)

Exome-Wide Association Study Identified Clusters of Pleiotropic Genetic Associations with Alzheimer’s Disease and Thirteen Cardiovascular Traits
por: Loika, Yury, et al.
Publicado: (2023)

Associations of the APOE ε2 and ε4 alleles and polygenic profiles comprising APOE-TOMM40-APOC1 variants with Alzheimer’s disease biomarkers
por: Kulminski, Alexander M., et al.
Publicado: (2022)

Apolipoprotein E region molecular signatures of Alzheimer's disease
por: Kulminski, Alexander M., et al.
Publicado: (2018)

Haplotype architecture of the Alzheimer's risk in the APOE region via co‐skewness
por: Kulminski, Alexander M., et al.
Publicado: (2020)

GENOME-WIDE META-ANALYSIS SUPPORTS HETEROGENEITY IN POLYGENIC ARCHITECTURE OF DISABILITY
por: Kulminski, Alexander, et al.
Publicado: (2019)

Genetic and regulatory architecture of Alzheimer's disease in the APOE region
por: Kulminski, Alexander M., et al.
Publicado: (2020)

An Approach to Identify New Pleiotropic Genetic Loci From Publicly Available Univariate GWAS Results
por: Loika, Yury, et al.
Publicado: (2020)

Allele-specific analysis reveals exon- and cell-type-specific regulatory effects of Alzheimer’s disease-associated genetic variants
por: He, Liang, et al.
Publicado: (2022)

Exogenous exposures shape genetic predisposition to lipids, Alzheimer’s, and coronary heart disease in the MLXIPL gene locus
por: Loika, Yury, et al.
Publicado: (2023)

Explicating heterogeneity of complex traits has strong potential for improving GWAS efficiency
por: Kulminski, Alexander M., et al.
Publicado: (2016)

Strong impact of natural-selection–free heterogeneity in genetics of age-related phenotypes
por: Kulminski, Alexander M., et al.
Publicado: (2018)

Pleiotropic Meta-Analysis of Age-Related Phenotypes Addressing Evolutionary Uncertainty in Their Molecular Mechanisms
por: Kulminski, Alexander M., et al.
Publicado: (2019)

Pleiotropic Associations of Allelic Variants in a 2q22 Region with Risks of Major Human Diseases and Mortality
por: Kulminski, Alexander M., et al.
Publicado: (2016)

APOE ɛ4 allele and TOMM40‐APOC1 variants jointly contribute to survival to older ages
por: Kulminski, Alexander M., et al.
Publicado: (2022)

Inter- and intra-chromosomal modulators of the APOE ɛ2 and ɛ4 effects on the Alzheimer’s disease risk
por: Nazarian, Alireza, et al.
Publicado: (2022)

Uncoupling associations of risk alleles with endophenotypes and phenotypes: insights from the ApoB locus and heart‐related traits
por: Kulminski, Alexander M., et al.
Publicado: (2016)

Discordant associations of educational attainment with ASD and ADHD implicate a polygenic form of pleiotropy
por: Verhoef, Ellen, et al.
Publicado: (2021)

Exome-wide age-of-onset analysis reveals exonic variants in ERN1 and SPPL2C associated with Alzheimer’s disease
por: He, Liang, et al.
Publicado: (2021)

Independent associations of TOMM40 and APOE variants with body mass index
por: Kulminski, Alexander M., et al.
Publicado: (2018)

Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases
por: He, Liang, et al.
Publicado: (2016)

Corrigendum: Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases
por: He, Liang, et al.
Publicado: (2018)

Lossless integration of multiple electronic health records for identifying pleiotropy using summary statistics
por: Li, Ruowang, et al.
Publicado: (2021)

Polygenic pleiotropy and potential causal relationships between educational attainment, neurobiological profile, and positive psychotic symptoms
por: Lin, Yen-Feng, et al.
Publicado: (2018)

Using Threshold Regression as an Approach to Incorporate Informative Missingness in Long Life Family Study Data
por: Zhbannikov, Ilya, et al.
Publicado: (2021)

Mendelian randomization for causal inference accounting for pleiotropy and sample structure using genome-wide summary statistics
por: Hu, Xianghong, et al.
Publicado: (2022)

Summary-Based Methylome-Wide Association Analyses Suggest Potential Genetically Driven Epigenetic Heterogeneity of Alzheimer’s Disease
por: Nazarian, Alireza, et al.
Publicado: (2020)

Genomic variation in educational attainment modifies Alzheimer disease risk
por: Raghavan, Neha S., et al.
Publicado: (2019)

MR-LDP: a two-sample Mendelian randomization for GWAS summary statistics accounting for linkage disequilibrium and horizontal pleiotropy
por: Cheng, Qing, et al.
Publicado: (2020)

Genes Involved in Physiological Dysregulation and Decline in Resilience: Role in Alzheimer’s Disease
por: Ukraintseva, Svetlana, et al.
Publicado: (2021)

Statistical methods to detect pleiotropy in human complex traits
por: Hackinger, Sophie, et al.
Publicado: (2017)

Adult Children’s Education Attainment and Parents’ Subjective Well-Being in China
por: Chen, Dan, et al.
Publicado: (2020)

ADULT CHILDREN'S EDUCATIONAL ATTAINMENT AND PARENT HEALTH IN MID- AND LATER LIFE
por: Dennison, Christopher, et al.
Publicado: (2022)

Role of Genetic Interactions in Alzheimer’s Disease: Lessons from Long Life Family Study (LLFS)
por: Yashin, Anatoliy, et al.
Publicado: (2020)

Genome-wide pleiotropy analysis of neuropathological traits related to Alzheimer’s disease
por: Chung, Jaeyoon, et al.
Publicado: (2018)

A framework for the investigation of pleiotropy in two‐sample summary data Mendelian randomization
por: Bowden, Jack, et al.
Publicado: (2017)

Cognitive Activity as a Moderator of Educational Attainment and Work Status in Cognitive Aging
por: Stieger, Mirjam, et al.
Publicado: (2020)

Does Familial Educational Attainment Predict Sleep Quality Trajectories for Older Adults in Mexico?
por: Sheehan, Connor, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_b3pdjo2sctle79ojrhqkv5ekf3