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Diabetes Mellitus, Edentulism, and Trajectory of Cognitive Decline Among Older Adults

We examined the impact of diabetes mellitus (DM) and edentulism on the trajectory of cognitive decline, using the Health and Retirement Study. We analyzed self-reported DM and edentulism collected in 2006 and cognition data from 2006 and its follow up waves through 2018. Among 15,709 eligible partic...

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Autores principales: Wu, Bei, Tan, Chenxin, Plassman, Brenda, Sloan, Frank, Schwartz, Mark, Adhikari, Samrachana, Kamer, Angela, Luo, Huabin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8682613/
http://dx.doi.org/10.1093/geroni/igab046.791
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author Wu, Bei
Tan, Chenxin
Plassman, Brenda
Sloan, Frank
Schwartz, Mark
Adhikari, Samrachana
Kamer, Angela
Luo, Huabin
author_facet Wu, Bei
Tan, Chenxin
Plassman, Brenda
Sloan, Frank
Schwartz, Mark
Adhikari, Samrachana
Kamer, Angela
Luo, Huabin
author_sort Wu, Bei
collection PubMed
description We examined the impact of diabetes mellitus (DM) and edentulism on the trajectory of cognitive decline, using the Health and Retirement Study. We analyzed self-reported DM and edentulism collected in 2006 and cognition data from 2006 and its follow up waves through 2018. Among 15,709 eligible participants age 50+ in 2006, 65.96% had neither DM nor edentulism (Group 1), 15.12% had DM alone (Group 2), 13.79% had edentulism alone (Group 3), and 5.12% had both conditions (Group 4). Results from linear mixed-effects models show that in comparison to Group 1, individuals in Group 4 had the lowest level of cognitive function, followed by those in Group 3 and Group 2. Group 4 had a modestly faster rate of cognitive decline (p=0.052). This study illustrates that co-occurrence of DM and edentulism has a higher risk of more rapid cognitive decline with advancing age than the presence of each condition alone.
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spelling pubmed-86826132021-12-17 Diabetes Mellitus, Edentulism, and Trajectory of Cognitive Decline Among Older Adults Wu, Bei Tan, Chenxin Plassman, Brenda Sloan, Frank Schwartz, Mark Adhikari, Samrachana Kamer, Angela Luo, Huabin Innov Aging Abstracts We examined the impact of diabetes mellitus (DM) and edentulism on the trajectory of cognitive decline, using the Health and Retirement Study. We analyzed self-reported DM and edentulism collected in 2006 and cognition data from 2006 and its follow up waves through 2018. Among 15,709 eligible participants age 50+ in 2006, 65.96% had neither DM nor edentulism (Group 1), 15.12% had DM alone (Group 2), 13.79% had edentulism alone (Group 3), and 5.12% had both conditions (Group 4). Results from linear mixed-effects models show that in comparison to Group 1, individuals in Group 4 had the lowest level of cognitive function, followed by those in Group 3 and Group 2. Group 4 had a modestly faster rate of cognitive decline (p=0.052). This study illustrates that co-occurrence of DM and edentulism has a higher risk of more rapid cognitive decline with advancing age than the presence of each condition alone. Oxford University Press 2021-12-17 /pmc/articles/PMC8682613/ http://dx.doi.org/10.1093/geroni/igab046.791 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of The Gerontological Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstracts
Wu, Bei
Tan, Chenxin
Plassman, Brenda
Sloan, Frank
Schwartz, Mark
Adhikari, Samrachana
Kamer, Angela
Luo, Huabin
Diabetes Mellitus, Edentulism, and Trajectory of Cognitive Decline Among Older Adults
title Diabetes Mellitus, Edentulism, and Trajectory of Cognitive Decline Among Older Adults
title_full Diabetes Mellitus, Edentulism, and Trajectory of Cognitive Decline Among Older Adults
title_fullStr Diabetes Mellitus, Edentulism, and Trajectory of Cognitive Decline Among Older Adults
title_full_unstemmed Diabetes Mellitus, Edentulism, and Trajectory of Cognitive Decline Among Older Adults
title_short Diabetes Mellitus, Edentulism, and Trajectory of Cognitive Decline Among Older Adults
title_sort diabetes mellitus, edentulism, and trajectory of cognitive decline among older adults
topic Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8682613/
http://dx.doi.org/10.1093/geroni/igab046.791
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