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Vision, Cognitive Impairment, and Dementia in the Aging, Demographics, and Memory Study

Vision impairment (VI) is common in late-life and may be a modifiable risk factor for cognitive decline and dementia. In this study, using data from the population-based Aging, Demographics and Memory Study (ADAMS), we analyzed the association of VI with cognitive impairment no dementia (CIND) and d...

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Autores principales: Ehrlich, Joshua, Swenor, Bonnielin, Zhou, Yunshu, Langa, Kenneth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8682716/
http://dx.doi.org/10.1093/geroni/igab046.594
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author Ehrlich, Joshua
Swenor, Bonnielin
Zhou, Yunshu
Langa, Kenneth
author_facet Ehrlich, Joshua
Swenor, Bonnielin
Zhou, Yunshu
Langa, Kenneth
author_sort Ehrlich, Joshua
collection PubMed
description Vision impairment (VI) is common in late-life and may be a modifiable risk factor for cognitive decline and dementia. In this study, using data from the population-based Aging, Demographics and Memory Study (ADAMS), we analyzed the association of VI with cognitive impairment no dementia (CIND) and dementia. We found that VI (binocular presenting acuity <20/40) was significantly associated with incident CIND (OR=3.5, 95% CI=1.4-8.9, p=0.008) and dementia (OR=1.8, 95% CI=1.0-3.1, p=0.040) after adjusting for age. However, among those with CIND, VI was not associated with dementia (OR=0.9, 95% CI=0.4-1.8, p=0.733). The association between VI and CIND remained significant in models fully adjusted for demographic and health factors (OR=2.7, 95% CI=1.0-7.5, p=0.049). We conclude that VI is associated with development of CIND but not with subsequent onset of dementia. These findings suggest that the association between VI and dementia is driven by the elevated risk of dementia among those with CIND.
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spelling pubmed-86827162021-12-20 Vision, Cognitive Impairment, and Dementia in the Aging, Demographics, and Memory Study Ehrlich, Joshua Swenor, Bonnielin Zhou, Yunshu Langa, Kenneth Innov Aging Abstracts Vision impairment (VI) is common in late-life and may be a modifiable risk factor for cognitive decline and dementia. In this study, using data from the population-based Aging, Demographics and Memory Study (ADAMS), we analyzed the association of VI with cognitive impairment no dementia (CIND) and dementia. We found that VI (binocular presenting acuity <20/40) was significantly associated with incident CIND (OR=3.5, 95% CI=1.4-8.9, p=0.008) and dementia (OR=1.8, 95% CI=1.0-3.1, p=0.040) after adjusting for age. However, among those with CIND, VI was not associated with dementia (OR=0.9, 95% CI=0.4-1.8, p=0.733). The association between VI and CIND remained significant in models fully adjusted for demographic and health factors (OR=2.7, 95% CI=1.0-7.5, p=0.049). We conclude that VI is associated with development of CIND but not with subsequent onset of dementia. These findings suggest that the association between VI and dementia is driven by the elevated risk of dementia among those with CIND. Oxford University Press 2021-12-17 /pmc/articles/PMC8682716/ http://dx.doi.org/10.1093/geroni/igab046.594 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of The Gerontological Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstracts
Ehrlich, Joshua
Swenor, Bonnielin
Zhou, Yunshu
Langa, Kenneth
Vision, Cognitive Impairment, and Dementia in the Aging, Demographics, and Memory Study
title Vision, Cognitive Impairment, and Dementia in the Aging, Demographics, and Memory Study
title_full Vision, Cognitive Impairment, and Dementia in the Aging, Demographics, and Memory Study
title_fullStr Vision, Cognitive Impairment, and Dementia in the Aging, Demographics, and Memory Study
title_full_unstemmed Vision, Cognitive Impairment, and Dementia in the Aging, Demographics, and Memory Study
title_short Vision, Cognitive Impairment, and Dementia in the Aging, Demographics, and Memory Study
title_sort vision, cognitive impairment, and dementia in the aging, demographics, and memory study
topic Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8682716/
http://dx.doi.org/10.1093/geroni/igab046.594
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