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Specificity and sensitivity of an RNA targeting type III CRISPR complex coupled with a NucC endonuclease effector

Type III CRISPR systems detect invading RNA, resulting in the activation of the enzymatic Cas10 subunit. The Cas10 cyclase domain generates cyclic oligoadenylate (cOA) second messenger molecules, activating a variety of effector nucleases that degrade nucleic acids to provide immunity. The prophage-...

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Detalles Bibliográficos
Autores principales: Grüschow, Sabine, Adamson, Catherine S, White, Malcolm F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8682760/
https://www.ncbi.nlm.nih.gov/pubmed/34871408
http://dx.doi.org/10.1093/nar/gkab1190