Specificity and sensitivity of an RNA targeting type III CRISPR complex coupled with a NucC endonuclease effector

Type III CRISPR systems detect invading RNA, resulting in the activation of the enzymatic Cas10 subunit. The Cas10 cyclase domain generates cyclic oligoadenylate (cOA) second messenger molecules, activating a variety of effector nucleases that degrade nucleic acids to provide immunity. The prophage-...

Descripción completa

Detalles Bibliográficos
Autores principales: Grüschow, Sabine, Adamson, Catherine S, White, Malcolm F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8682760/
https://www.ncbi.nlm.nih.gov/pubmed/34871408
http://dx.doi.org/10.1093/nar/gkab1190

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8682760/
https://www.ncbi.nlm.nih.gov/pubmed/34871408
http://dx.doi.org/10.1093/nar/gkab1190

Ejemplares similares