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Specificity and sensitivity of an RNA targeting type III CRISPR complex coupled with a NucC endonuclease effector
Type III CRISPR systems detect invading RNA, resulting in the activation of the enzymatic Cas10 subunit. The Cas10 cyclase domain generates cyclic oligoadenylate (cOA) second messenger molecules, activating a variety of effector nucleases that degrade nucleic acids to provide immunity. The prophage-...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8682760/ https://www.ncbi.nlm.nih.gov/pubmed/34871408 http://dx.doi.org/10.1093/nar/gkab1190 |