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Abnormal migration behavior linked to Rac1 signaling contributes to primordial germ cell exhaustion in Fanconi anemia pathway-deficient Fancg(−/−) embryos

Fanconi anemia (FA) is a rare human genetic disorder characterized by bone marrow failure, predisposition to cancer and developmental defects including hypogonadism. Reproductive defects leading to germ cell aplasia are the most consistent phenotypes seen in FA mouse models. We examined the role of...

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Detalles Bibliográficos
Autores principales:	Jarysta, Amandine, Riou, Lydia, Firlej, Virginie, Lapoujade, Clémentine, Kortulewski, Thierry, Barroca, Vilma, Gille, Anne-Sophie, Dumont, Florent, Jacques, Sébastien, Letourneur, Franck, Rosselli, Filippo, Allemand, Isabelle, Fouchet, Pierre
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	General Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8682768/ https://www.ncbi.nlm.nih.gov/pubmed/34368842 http://dx.doi.org/10.1093/hmg/ddab222

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