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TIN2 is an architectural protein that facilitates TRF2-mediated trans- and cis-interactions on telomeric DNA

The telomere specific shelterin complex, which includes TRF1, TRF2, RAP1, TIN2, TPP1 and POT1, prevents spurious recognition of telomeres as double-strand DNA breaks and regulates telomerase and DNA repair activities at telomeres. TIN2 is a key component of the shelterin complex that directly intera...

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Detalles Bibliográficos
Autores principales:	Kaur, Parminder, Barnes, Ryan, Pan, Hai, Detwiler, Ariana C, Liu, Ming, Mahn, Chelsea, Hall, Jonathan, Messenger, Zach, You, Changjiang, Piehler, Jacob, Smart, Robert C, Riehn, Robert, Opresko, Patricia L, Wang, Hong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8682769/ https://www.ncbi.nlm.nih.gov/pubmed/34883513 http://dx.doi.org/10.1093/nar/gkab1142

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