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Elongating RNA polymerase II and RNA:DNA hybrids hinder fork progression and gene expression at sites of head-on replication-transcription collisions

Uncoordinated clashes between replication forks and transcription cause replication stress and genome instability, which are hallmarks of cancer and neurodegeneration. Here, we investigate the outcomes of head-on replication-transcription collisions, using as a model system budding yeast mutants for...

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Detalles Bibliográficos
Autores principales:	Zardoni, Luca, Nardini, Eleonora, Brambati, Alessandra, Lucca, Chiara, Choudhary, Ramveer, Loperfido, Federica, Sabbioneda, Simone, Liberi, Giordano
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8682787/ https://www.ncbi.nlm.nih.gov/pubmed/34878142 http://dx.doi.org/10.1093/nar/gkab1146

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