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Caught in motion: human NTHL1 undergoes interdomain rearrangement necessary for catalysis

Base excision repair (BER) is the main pathway protecting cells from the continuous damage to DNA inflicted by reactive oxygen species. BER is initiated by DNA glycosylases, each of which repairs a particular class of base damage. NTHL1, a bifunctional DNA glycosylase, possesses both glycolytic and...

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Detalles Bibliográficos
Autores principales:	Carroll, Brittany L, Zahn, Karl E, Hanley, John P, Wallace, Susan S, Dragon, Julie A, Doublié, Sylvie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8682792/ https://www.ncbi.nlm.nih.gov/pubmed/34871433 http://dx.doi.org/10.1093/nar/gkab1162

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