A pathogenic role for histone H3 copper reductase activity in a yeast model of Friedreich’s ataxia

Disruptions to iron-sulfur (Fe-S) clusters, essential cofactors for a broad range of proteins, cause widespread cellular defects resulting in human disease. A source of damage to Fe-S clusters is cuprous (Cu(1+)) ions. Since histone H3 enzymatically produces Cu(1+) for copper-dependent functions, we...

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Detalles Bibliográficos
Autores principales: Campos, Oscar A., Attar, Narsis, Cheng, Chen, Vogelauer, Maria, Mallipeddi, Nathan V., Schmollinger, Stefan, Matulionis, Nedas, Christofk, Heather R., Merchant, Sabeeha S., Kurdistani, Siavash K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8682991/
https://www.ncbi.nlm.nih.gov/pubmed/34919435
http://dx.doi.org/10.1126/sciadv.abj9889

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