Ceftolozane-tazobactam: When, how and why using it?

Ceftolozane-tazobactam is currently the most active antipseudomonal agent, including multidrug-resistant extensively drug-resistant strains. Tazobactam provides additional activity against many extended-spectrum beta-lactamases Enterobacterales. Ceftolozane-tazobactam is formally approved for compli...

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Detalles Bibliográficos
Autores principales: López, Inmaculada, Montesinos, Montero, Milagro, Sorlí, Luisa, Horcajada, Juan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedad Española de Quimioterapia 2021
Materias:
Update on Antimicrobial Pharmacotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8682999/
https://www.ncbi.nlm.nih.gov/pubmed/34598422
http://dx.doi.org/10.37201/req/s01.10.2021
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author López, Inmaculada
Montesinos,
Montero, Milagro
Sorlí, Luisa
Horcajada, Juan P.
author_facet López, Inmaculada
Montesinos,
Montero, Milagro
Sorlí, Luisa
Horcajada, Juan P.
author_sort López, Inmaculada
collection PubMed
description Ceftolozane-tazobactam is currently the most active antipseudomonal agent, including multidrug-resistant extensively drug-resistant strains. Tazobactam provides additional activity against many extended-spectrum beta-lactamases Enterobacterales. Ceftolozane-tazobactam is formally approved for complicated urinary tract infection, complicated intra-abdominal infection, and hospital-acquired and ventilator-associated bacterial pneumonia. The clinical and microbiological success is over 70-80% in many series. However, resistant mutants to ceftolozane-tazobactam have been already described. Combination therapies with colistin or meropenem could be among the strategies to avoid the resistance emergence.
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spelling pubmed-86829992021-12-29 Ceftolozane-tazobactam: When, how and why using it? López, Inmaculada Montesinos, Montero, Milagro Sorlí, Luisa Horcajada, Juan P. Rev Esp Quimioter Update on Antimicrobial Pharmacotherapy Ceftolozane-tazobactam is currently the most active antipseudomonal agent, including multidrug-resistant extensively drug-resistant strains. Tazobactam provides additional activity against many extended-spectrum beta-lactamases Enterobacterales. Ceftolozane-tazobactam is formally approved for complicated urinary tract infection, complicated intra-abdominal infection, and hospital-acquired and ventilator-associated bacterial pneumonia. The clinical and microbiological success is over 70-80% in many series. However, resistant mutants to ceftolozane-tazobactam have been already described. Combination therapies with colistin or meropenem could be among the strategies to avoid the resistance emergence. Sociedad Española de Quimioterapia 2021-09-30 2021 /pmc/articles/PMC8682999/ /pubmed/34598422 http://dx.doi.org/10.37201/req/s01.10.2021 Text en © The Author 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)(https://creativecommons.org/licenses/by-nc/4.0/).
spellingShingle Update on Antimicrobial Pharmacotherapy
López, Inmaculada
Montesinos,
Montero, Milagro
Sorlí, Luisa
Horcajada, Juan P.
Ceftolozane-tazobactam: When, how and why using it?
title Ceftolozane-tazobactam: When, how and why using it?
title_full Ceftolozane-tazobactam: When, how and why using it?
title_fullStr Ceftolozane-tazobactam: When, how and why using it?
title_full_unstemmed Ceftolozane-tazobactam: When, how and why using it?
title_short Ceftolozane-tazobactam: When, how and why using it?
title_sort ceftolozane-tazobactam: when, how and why using it?
topic Update on Antimicrobial Pharmacotherapy
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8682999/
https://www.ncbi.nlm.nih.gov/pubmed/34598422
http://dx.doi.org/10.37201/req/s01.10.2021
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