Treatment of infections caused by multi-resistant microorganisms in hospital at home units

Hospital at home units allow the treatment of moderate and severe infections by administering intravenous antibiotics to patients who would otherwise have to remain hospitalised. Increasing antibiotic resistance adds an element of difficulty to outpatient treatment of infections because multiple daily doses of antimicrobials or combinations of antimicrobials are sometimes required. This manuscript discusses some of the challenges of outpatient management of infections with multidrug-resistant microorganisms and shows the main antibiotic resistances and the outcomes of treatment of these infections in Spanish home hospitalisation units.