S-acylation by ZDHHC20 targets ORAI1 channels to lipid rafts for efficient Ca(2+) signaling by Jurkat T cell receptors at the immune synapse

Efficient immune responses require Ca(2+) fluxes across ORAI1 channels during engagement of T cell receptors (TCR) at the immune synapse (IS) between T cells and antigen presenting cells. Here, we show that ZDHHC20-mediated S-acylation of the ORAI1 channel at residue Cys143 promotes TCR recruitment...

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Detalles Bibliográficos
Autores principales: Carreras-Sureda, Amado, Abrami, Laurence, Ji-Hee, Kim, Wang, Wen-An, Henry, Christopher, Frieden, Maud, Didier, Monica, van der Goot, F Gisou, Demaurex, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8683079/
https://www.ncbi.nlm.nih.gov/pubmed/34913437
http://dx.doi.org/10.7554/eLife.72051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8683079/
https://www.ncbi.nlm.nih.gov/pubmed/34913437
http://dx.doi.org/10.7554/eLife.72051

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