Antigenic evolution of human influenza H3N2 neuraminidase is constrained by charge balancing

As one of the main influenza antigens, neuraminidase (NA) in H3N2 virus has evolved extensively for more than 50 years due to continuous immune pressure. While NA has recently emerged as an effective vaccine target, biophysical constraints on the antigenic evolution of NA remain largely elusive. Her...

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Detalles Bibliográficos
Autores principales: Wang, Yiquan, Lei, Ruipeng, Nourmohammad, Armita, Wu, Nicholas C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Evolutionary Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8683081/
https://www.ncbi.nlm.nih.gov/pubmed/34878407
http://dx.doi.org/10.7554/eLife.72516

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8683081/
https://www.ncbi.nlm.nih.gov/pubmed/34878407
http://dx.doi.org/10.7554/eLife.72516

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