Successful Treatment of Thrombocytopenia, Anasarca, Fever, Reticulin Myelofibrosis/Renal Insufficiency, and Organomegaly Syndrome Using Plasma Exchange Followed by Rituximab in the Intensive Care Unit

Thrombocytopenia, anasarca, fever, reticulin myelofibrosis/renal insufficiency, and organomegaly (TAFRO) syndrome is treated using corticosteroids and/or immunosuppressive agents as first-line therapy. We report the case of a 69-year-old female with TAFRO syndrome in which the patient presented mult...

Descripción completa

Detalles Bibliográficos
Autores principales: Otsuka, Yusuke, Shirakabe, Akihiro, Asayama, Toshio, Okazaki, Hirotake, Shibata, Yusaku, Shigihara, Shota, Sawatani, Tomofumi, Yokose, Norio, Asai, Kuniya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8683112/
https://www.ncbi.nlm.nih.gov/pubmed/34970369
http://dx.doi.org/10.14740/jmc3784
_version_ 1784617343039569920
author Otsuka, Yusuke
Shirakabe, Akihiro
Asayama, Toshio
Okazaki, Hirotake
Shibata, Yusaku
Shigihara, Shota
Sawatani, Tomofumi
Yokose, Norio
Asai, Kuniya
author_facet Otsuka, Yusuke
Shirakabe, Akihiro
Asayama, Toshio
Okazaki, Hirotake
Shibata, Yusaku
Shigihara, Shota
Sawatani, Tomofumi
Yokose, Norio
Asai, Kuniya
author_sort Otsuka, Yusuke
collection PubMed
description Thrombocytopenia, anasarca, fever, reticulin myelofibrosis/renal insufficiency, and organomegaly (TAFRO) syndrome is treated using corticosteroids and/or immunosuppressive agents as first-line therapy. We report the case of a 69-year-old female with TAFRO syndrome in which the patient presented multiple organ failure and steroid resistance, which was successfully treated using plasma exchange (PE) followed by rituximab. Decisions regarding the next treatment, including PE, are urgent for patients with steroid-resistant TAFRO syndrome. Since it is considered that immunosuppressive agents may be removed by PE, the performance of PE before treatment with immunosuppressive agents might be an option for steroid-resistant TAFRO syndrome.
format Online
Article
Text
id pubmed-8683112
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Elmer Press
record_format MEDLINE/PubMed
spelling pubmed-86831122021-12-29 Successful Treatment of Thrombocytopenia, Anasarca, Fever, Reticulin Myelofibrosis/Renal Insufficiency, and Organomegaly Syndrome Using Plasma Exchange Followed by Rituximab in the Intensive Care Unit Otsuka, Yusuke Shirakabe, Akihiro Asayama, Toshio Okazaki, Hirotake Shibata, Yusaku Shigihara, Shota Sawatani, Tomofumi Yokose, Norio Asai, Kuniya J Med Cases Case Report Thrombocytopenia, anasarca, fever, reticulin myelofibrosis/renal insufficiency, and organomegaly (TAFRO) syndrome is treated using corticosteroids and/or immunosuppressive agents as first-line therapy. We report the case of a 69-year-old female with TAFRO syndrome in which the patient presented multiple organ failure and steroid resistance, which was successfully treated using plasma exchange (PE) followed by rituximab. Decisions regarding the next treatment, including PE, are urgent for patients with steroid-resistant TAFRO syndrome. Since it is considered that immunosuppressive agents may be removed by PE, the performance of PE before treatment with immunosuppressive agents might be an option for steroid-resistant TAFRO syndrome. Elmer Press 2021-12 2021-12-02 /pmc/articles/PMC8683112/ /pubmed/34970369 http://dx.doi.org/10.14740/jmc3784 Text en Copyright 2021, Otsuka et al. https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Otsuka, Yusuke
Shirakabe, Akihiro
Asayama, Toshio
Okazaki, Hirotake
Shibata, Yusaku
Shigihara, Shota
Sawatani, Tomofumi
Yokose, Norio
Asai, Kuniya
Successful Treatment of Thrombocytopenia, Anasarca, Fever, Reticulin Myelofibrosis/Renal Insufficiency, and Organomegaly Syndrome Using Plasma Exchange Followed by Rituximab in the Intensive Care Unit
title Successful Treatment of Thrombocytopenia, Anasarca, Fever, Reticulin Myelofibrosis/Renal Insufficiency, and Organomegaly Syndrome Using Plasma Exchange Followed by Rituximab in the Intensive Care Unit
title_full Successful Treatment of Thrombocytopenia, Anasarca, Fever, Reticulin Myelofibrosis/Renal Insufficiency, and Organomegaly Syndrome Using Plasma Exchange Followed by Rituximab in the Intensive Care Unit
title_fullStr Successful Treatment of Thrombocytopenia, Anasarca, Fever, Reticulin Myelofibrosis/Renal Insufficiency, and Organomegaly Syndrome Using Plasma Exchange Followed by Rituximab in the Intensive Care Unit
title_full_unstemmed Successful Treatment of Thrombocytopenia, Anasarca, Fever, Reticulin Myelofibrosis/Renal Insufficiency, and Organomegaly Syndrome Using Plasma Exchange Followed by Rituximab in the Intensive Care Unit
title_short Successful Treatment of Thrombocytopenia, Anasarca, Fever, Reticulin Myelofibrosis/Renal Insufficiency, and Organomegaly Syndrome Using Plasma Exchange Followed by Rituximab in the Intensive Care Unit
title_sort successful treatment of thrombocytopenia, anasarca, fever, reticulin myelofibrosis/renal insufficiency, and organomegaly syndrome using plasma exchange followed by rituximab in the intensive care unit
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8683112/
https://www.ncbi.nlm.nih.gov/pubmed/34970369
http://dx.doi.org/10.14740/jmc3784
work_keys_str_mv AT otsukayusuke successfultreatmentofthrombocytopeniaanasarcafeverreticulinmyelofibrosisrenalinsufficiencyandorganomegalysyndromeusingplasmaexchangefollowedbyrituximabintheintensivecareunit
AT shirakabeakihiro successfultreatmentofthrombocytopeniaanasarcafeverreticulinmyelofibrosisrenalinsufficiencyandorganomegalysyndromeusingplasmaexchangefollowedbyrituximabintheintensivecareunit
AT asayamatoshio successfultreatmentofthrombocytopeniaanasarcafeverreticulinmyelofibrosisrenalinsufficiencyandorganomegalysyndromeusingplasmaexchangefollowedbyrituximabintheintensivecareunit
AT okazakihirotake successfultreatmentofthrombocytopeniaanasarcafeverreticulinmyelofibrosisrenalinsufficiencyandorganomegalysyndromeusingplasmaexchangefollowedbyrituximabintheintensivecareunit
AT shibatayusaku successfultreatmentofthrombocytopeniaanasarcafeverreticulinmyelofibrosisrenalinsufficiencyandorganomegalysyndromeusingplasmaexchangefollowedbyrituximabintheintensivecareunit
AT shigiharashota successfultreatmentofthrombocytopeniaanasarcafeverreticulinmyelofibrosisrenalinsufficiencyandorganomegalysyndromeusingplasmaexchangefollowedbyrituximabintheintensivecareunit
AT sawatanitomofumi successfultreatmentofthrombocytopeniaanasarcafeverreticulinmyelofibrosisrenalinsufficiencyandorganomegalysyndromeusingplasmaexchangefollowedbyrituximabintheintensivecareunit
AT yokosenorio successfultreatmentofthrombocytopeniaanasarcafeverreticulinmyelofibrosisrenalinsufficiencyandorganomegalysyndromeusingplasmaexchangefollowedbyrituximabintheintensivecareunit
AT asaikuniya successfultreatmentofthrombocytopeniaanasarcafeverreticulinmyelofibrosisrenalinsufficiencyandorganomegalysyndromeusingplasmaexchangefollowedbyrituximabintheintensivecareunit

Ejemplares similares