Cargando…

Mitochondrial Damage-associated Molecular Patterns as Potential Biomarkers in DCD Heart Transplantation: Lessons From Myocardial Infarction and Cardiac Arrest

Heart transplantation with donation after circulatory death (DCD) has become a real option to increase graft availability. However, given that DCD organs are exposed to the potentially damaging conditions of warm ischemia before procurement, new strategies for graft evaluation are of particular valu...

Descripción completa

Detalles Bibliográficos
Autores principales: Longnus, Sarah L., Rutishauser, Nina, Gillespie, Mark N., Reichlin, Tobias, Carrel, Thierry P., Sanz, Maria N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8683216/
https://www.ncbi.nlm.nih.gov/pubmed/34934807
http://dx.doi.org/10.1097/TXD.0000000000001265
_version_ 1784617365741240320
author Longnus, Sarah L.
Rutishauser, Nina
Gillespie, Mark N.
Reichlin, Tobias
Carrel, Thierry P.
Sanz, Maria N.
author_facet Longnus, Sarah L.
Rutishauser, Nina
Gillespie, Mark N.
Reichlin, Tobias
Carrel, Thierry P.
Sanz, Maria N.
author_sort Longnus, Sarah L.
collection PubMed
description Heart transplantation with donation after circulatory death (DCD) has become a real option to increase graft availability. However, given that DCD organs are exposed to the potentially damaging conditions of warm ischemia before procurement, new strategies for graft evaluation are of particular value for the safe expansion of DCD heart transplantation. Mitochondria-related parameters are very attractive as biomarkers because of their intimate association with cardiac ischemia-reperfusion injury. In this context, a group of mitochondrial components, called mitochondrial damage-associated molecular patterns (mtDAMPs), released by stressed cells, holds great promise. mtDAMPs may be released at different stages of DCD cardiac donation and may act as indicators of graft quality. Because of the lack of information available for DCD grafts, we consider that relevant information can be obtained from other acute cardiac ischemic conditions. Thus, we conducted a systematic review of original research articles in which mtDAMP levels were assessed in the circulation of patients with acute myocardial infarction and cardiac arrest. We conclude that 4 mtDAMPs, ATP, cytochrome c, mitochondrial DNA, and succinate, are rapidly released into the circulation after the onset of ischemia, and their concentrations increase with reperfusion. Importantly, circulating levels of mtDAMPs correlate with cardiac damage and may be used as prognostic markers for patient survival in these conditions. Taken together, these findings support the concept that mtDAMPs may be of use as biomarkers to assess the transplant suitability of procured DCD hearts, and ultimately aid in facilitating the safe, widespread adoption of DCD heart transplantation.
format Online
Article
Text
id pubmed-8683216
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Lippincott Williams & Wilkins
record_format MEDLINE/PubMed
spelling pubmed-86832162021-12-20 Mitochondrial Damage-associated Molecular Patterns as Potential Biomarkers in DCD Heart Transplantation: Lessons From Myocardial Infarction and Cardiac Arrest Longnus, Sarah L. Rutishauser, Nina Gillespie, Mark N. Reichlin, Tobias Carrel, Thierry P. Sanz, Maria N. Transplant Direct Heart Transplantation Heart transplantation with donation after circulatory death (DCD) has become a real option to increase graft availability. However, given that DCD organs are exposed to the potentially damaging conditions of warm ischemia before procurement, new strategies for graft evaluation are of particular value for the safe expansion of DCD heart transplantation. Mitochondria-related parameters are very attractive as biomarkers because of their intimate association with cardiac ischemia-reperfusion injury. In this context, a group of mitochondrial components, called mitochondrial damage-associated molecular patterns (mtDAMPs), released by stressed cells, holds great promise. mtDAMPs may be released at different stages of DCD cardiac donation and may act as indicators of graft quality. Because of the lack of information available for DCD grafts, we consider that relevant information can be obtained from other acute cardiac ischemic conditions. Thus, we conducted a systematic review of original research articles in which mtDAMP levels were assessed in the circulation of patients with acute myocardial infarction and cardiac arrest. We conclude that 4 mtDAMPs, ATP, cytochrome c, mitochondrial DNA, and succinate, are rapidly released into the circulation after the onset of ischemia, and their concentrations increase with reperfusion. Importantly, circulating levels of mtDAMPs correlate with cardiac damage and may be used as prognostic markers for patient survival in these conditions. Taken together, these findings support the concept that mtDAMPs may be of use as biomarkers to assess the transplant suitability of procured DCD hearts, and ultimately aid in facilitating the safe, widespread adoption of DCD heart transplantation. Lippincott Williams & Wilkins 2021-12-16 /pmc/articles/PMC8683216/ /pubmed/34934807 http://dx.doi.org/10.1097/TXD.0000000000001265 Text en Copyright © 2021 The Author(s). Transplantation Direct. Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Heart Transplantation
Longnus, Sarah L.
Rutishauser, Nina
Gillespie, Mark N.
Reichlin, Tobias
Carrel, Thierry P.
Sanz, Maria N.
Mitochondrial Damage-associated Molecular Patterns as Potential Biomarkers in DCD Heart Transplantation: Lessons From Myocardial Infarction and Cardiac Arrest
title Mitochondrial Damage-associated Molecular Patterns as Potential Biomarkers in DCD Heart Transplantation: Lessons From Myocardial Infarction and Cardiac Arrest
title_full Mitochondrial Damage-associated Molecular Patterns as Potential Biomarkers in DCD Heart Transplantation: Lessons From Myocardial Infarction and Cardiac Arrest
title_fullStr Mitochondrial Damage-associated Molecular Patterns as Potential Biomarkers in DCD Heart Transplantation: Lessons From Myocardial Infarction and Cardiac Arrest
title_full_unstemmed Mitochondrial Damage-associated Molecular Patterns as Potential Biomarkers in DCD Heart Transplantation: Lessons From Myocardial Infarction and Cardiac Arrest
title_short Mitochondrial Damage-associated Molecular Patterns as Potential Biomarkers in DCD Heart Transplantation: Lessons From Myocardial Infarction and Cardiac Arrest
title_sort mitochondrial damage-associated molecular patterns as potential biomarkers in dcd heart transplantation: lessons from myocardial infarction and cardiac arrest
topic Heart Transplantation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8683216/
https://www.ncbi.nlm.nih.gov/pubmed/34934807
http://dx.doi.org/10.1097/TXD.0000000000001265
work_keys_str_mv AT longnussarahl mitochondrialdamageassociatedmolecularpatternsaspotentialbiomarkersindcdhearttransplantationlessonsfrommyocardialinfarctionandcardiacarrest
AT rutishausernina mitochondrialdamageassociatedmolecularpatternsaspotentialbiomarkersindcdhearttransplantationlessonsfrommyocardialinfarctionandcardiacarrest
AT gillespiemarkn mitochondrialdamageassociatedmolecularpatternsaspotentialbiomarkersindcdhearttransplantationlessonsfrommyocardialinfarctionandcardiacarrest
AT reichlintobias mitochondrialdamageassociatedmolecularpatternsaspotentialbiomarkersindcdhearttransplantationlessonsfrommyocardialinfarctionandcardiacarrest
AT carrelthierryp mitochondrialdamageassociatedmolecularpatternsaspotentialbiomarkersindcdhearttransplantationlessonsfrommyocardialinfarctionandcardiacarrest
AT sanzmarian mitochondrialdamageassociatedmolecularpatternsaspotentialbiomarkersindcdhearttransplantationlessonsfrommyocardialinfarctionandcardiacarrest