Cohort study of Covid-19 vaccine effectiveness among healthcare workers in Finland, December 2020 - October 2021

Recently, Covid-19 vaccine effectiveness has decreased especially against mild disease due to emergence of the Delta variant and waning protection. In this register-based study among healthcare workers in Finland, the vaccine effectiveness of two-dose mRNA vaccine series against SARS-CoV-2 infection...

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Autores principales: Poukka, Eero, Baum, Ulrike, Palmu, Arto A., Lehtonen, Toni O., Salo, Heini, Nohynek, Hanna, Leino, Tuija
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Ltd. 2022
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8683266/
https://www.ncbi.nlm.nih.gov/pubmed/34953607
http://dx.doi.org/10.1016/j.vaccine.2021.12.032
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author Poukka, Eero
Baum, Ulrike
Palmu, Arto A.
Lehtonen, Toni O.
Salo, Heini
Nohynek, Hanna
Leino, Tuija
author_facet Poukka, Eero
Baum, Ulrike
Palmu, Arto A.
Lehtonen, Toni O.
Salo, Heini
Nohynek, Hanna
Leino, Tuija
author_sort Poukka, Eero
collection PubMed
description Recently, Covid-19 vaccine effectiveness has decreased especially against mild disease due to emergence of the Delta variant and waning protection. In this register-based study among healthcare workers in Finland, the vaccine effectiveness of two-dose mRNA vaccine series against SARS-CoV-2 infection decreased from 82% (95% CI 79–85%) 14–90 days after vaccination to 53% (43–62%) after 6 months. Similar trend was observed for other series. Waning was not observed against Covid-19 hospitalization. These results facilitate decision-making of booster doses for healthcare workers.
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spelling pubmed-86832662021-12-20 Cohort study of Covid-19 vaccine effectiveness among healthcare workers in Finland, December 2020 - October 2021 Poukka, Eero Baum, Ulrike Palmu, Arto A. Lehtonen, Toni O. Salo, Heini Nohynek, Hanna Leino, Tuija Vaccine Short Communication Recently, Covid-19 vaccine effectiveness has decreased especially against mild disease due to emergence of the Delta variant and waning protection. In this register-based study among healthcare workers in Finland, the vaccine effectiveness of two-dose mRNA vaccine series against SARS-CoV-2 infection decreased from 82% (95% CI 79–85%) 14–90 days after vaccination to 53% (43–62%) after 6 months. Similar trend was observed for other series. Waning was not observed against Covid-19 hospitalization. These results facilitate decision-making of booster doses for healthcare workers. The Author(s). Published by Elsevier Ltd. 2022-01-31 2021-12-18 /pmc/articles/PMC8683266/ /pubmed/34953607 http://dx.doi.org/10.1016/j.vaccine.2021.12.032 Text en © 2021 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Short Communication
Poukka, Eero
Baum, Ulrike
Palmu, Arto A.
Lehtonen, Toni O.
Salo, Heini
Nohynek, Hanna
Leino, Tuija
Cohort study of Covid-19 vaccine effectiveness among healthcare workers in Finland, December 2020 - October 2021
title Cohort study of Covid-19 vaccine effectiveness among healthcare workers in Finland, December 2020 - October 2021
title_full Cohort study of Covid-19 vaccine effectiveness among healthcare workers in Finland, December 2020 - October 2021
title_fullStr Cohort study of Covid-19 vaccine effectiveness among healthcare workers in Finland, December 2020 - October 2021
title_full_unstemmed Cohort study of Covid-19 vaccine effectiveness among healthcare workers in Finland, December 2020 - October 2021
title_short Cohort study of Covid-19 vaccine effectiveness among healthcare workers in Finland, December 2020 - October 2021
title_sort cohort study of covid-19 vaccine effectiveness among healthcare workers in finland, december 2020 - october 2021
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8683266/
https://www.ncbi.nlm.nih.gov/pubmed/34953607
http://dx.doi.org/10.1016/j.vaccine.2021.12.032
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