Aberrant chromatin landscape following loss of the H3.3 chaperone Daxx in haematopoietic precursors leads to Pu.1-mediated neutrophilia and inflammation

Defective silencing of retrotransposable elements has been linked to inflammageing, cancer and autoimmune diseases. However, the underlying mechanisms are only partially understood. Here we implicate the histone H3.3 chaperone Daxx, a retrotransposable element repressor inactivated in myeloid leukae...

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Detalles Bibliográficos
Autores principales: Gerber, Julia P., Russ, Jenny, Chandrasekar, Vijay, Offermann, Nina, Lee, Hang-Mao, Spear, Sarah, Guzzi, Nicola, Maida, Simona, Pattabiraman, Sundararaghavan, Zhang, Ruoyu, Kayvanjoo, Amir H., Datta, Preeta, Kasturiarachchi, Jagath, Sposito, Teresa, Izotova, Natalia, Händler, Kristian, Adams, Peter D., Marafioti, Teresa, Enver, Tariq, Wenzel, Jörg, Beyer, Marc, Mass, Elvira, Bellodi, Cristian, Schultze, Joachim L., Capasso, Melania, Nimmo, Rachael, Salomoni, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8683376/
https://www.ncbi.nlm.nih.gov/pubmed/34876685
http://dx.doi.org/10.1038/s41556-021-00774-y

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