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Late presentation of chronic HBV and HCV patients seeking first time specialist care in Spain: a 2-year registry review
Chronic viral hepatitis infection affects an estimated 325 million people globally. People who initiate treatment after significant disease progression face increased risk of severe liver complications and death. Data are scarce on the characteristics and risk factors of people who present late to c...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8683418/ https://www.ncbi.nlm.nih.gov/pubmed/34921156 http://dx.doi.org/10.1038/s41598-021-01885-0 |
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author | Picchio, Camila A. Lens, Sabela Hernandez-Guerra, Manuel Arenas, Juan Andrade, Raúl J. Crespo, Javier García-Samaniego, Javier Romero-Gómez, Manuel Turnes, Juan Calleja, José Luis Simón, Miguel Ángel White, Trenton M. Riveiro-Barciela, Mar Pocurull, Anna Morales-Arraez, Dalia Gómez, Alexandra Buti, Maria Lazarus, Jeffrey V. |
author_facet | Picchio, Camila A. Lens, Sabela Hernandez-Guerra, Manuel Arenas, Juan Andrade, Raúl J. Crespo, Javier García-Samaniego, Javier Romero-Gómez, Manuel Turnes, Juan Calleja, José Luis Simón, Miguel Ángel White, Trenton M. Riveiro-Barciela, Mar Pocurull, Anna Morales-Arraez, Dalia Gómez, Alexandra Buti, Maria Lazarus, Jeffrey V. |
author_sort | Picchio, Camila A. |
collection | PubMed |
description | Chronic viral hepatitis infection affects an estimated 325 million people globally. People who initiate treatment after significant disease progression face increased risk of severe liver complications and death. Data are scarce on the characteristics and risk factors of people who present late to care in Spain and globally. Data were collected from January 2018 to December 2019 to report late presentation (LP) to specialist care at 11 large university hospitals in Spain to assess related risk factors using a multivariable logistic regression model. 2290 (CHB = 505, CHC = 1785) patients were analysed, with 581 (25.2%) presenting late. Hepatitis C patients more frequently reported LP compared to hepatitis B patients (28.1% vs 15.0%; p < 0.001). Older age (p < 0.001), being male (p < 0.001), being Spanish-born (p < 0.001), and having an unknown origin of referral (p = 0.08) were associated with a higher likelihood of LP. Advanced liver disease was identified in 533 (23%) patients and late-stage liver disease in 124 (5.4%). LP, including with irreversible liver damage, to viral hepatitis specialist care is frequent in Spain, despite being a country with unrestricted treatment access. Initiatives to reduce LP should specifically target men, older individuals, foreign-born populations for CHB, and Spanish nationals for CHC. |
format | Online Article Text |
id | pubmed-8683418 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-86834182021-12-20 Late presentation of chronic HBV and HCV patients seeking first time specialist care in Spain: a 2-year registry review Picchio, Camila A. Lens, Sabela Hernandez-Guerra, Manuel Arenas, Juan Andrade, Raúl J. Crespo, Javier García-Samaniego, Javier Romero-Gómez, Manuel Turnes, Juan Calleja, José Luis Simón, Miguel Ángel White, Trenton M. Riveiro-Barciela, Mar Pocurull, Anna Morales-Arraez, Dalia Gómez, Alexandra Buti, Maria Lazarus, Jeffrey V. Sci Rep Article Chronic viral hepatitis infection affects an estimated 325 million people globally. People who initiate treatment after significant disease progression face increased risk of severe liver complications and death. Data are scarce on the characteristics and risk factors of people who present late to care in Spain and globally. Data were collected from January 2018 to December 2019 to report late presentation (LP) to specialist care at 11 large university hospitals in Spain to assess related risk factors using a multivariable logistic regression model. 2290 (CHB = 505, CHC = 1785) patients were analysed, with 581 (25.2%) presenting late. Hepatitis C patients more frequently reported LP compared to hepatitis B patients (28.1% vs 15.0%; p < 0.001). Older age (p < 0.001), being male (p < 0.001), being Spanish-born (p < 0.001), and having an unknown origin of referral (p = 0.08) were associated with a higher likelihood of LP. Advanced liver disease was identified in 533 (23%) patients and late-stage liver disease in 124 (5.4%). LP, including with irreversible liver damage, to viral hepatitis specialist care is frequent in Spain, despite being a country with unrestricted treatment access. Initiatives to reduce LP should specifically target men, older individuals, foreign-born populations for CHB, and Spanish nationals for CHC. Nature Publishing Group UK 2021-12-17 /pmc/articles/PMC8683418/ /pubmed/34921156 http://dx.doi.org/10.1038/s41598-021-01885-0 Text en © Crown 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Picchio, Camila A. Lens, Sabela Hernandez-Guerra, Manuel Arenas, Juan Andrade, Raúl J. Crespo, Javier García-Samaniego, Javier Romero-Gómez, Manuel Turnes, Juan Calleja, José Luis Simón, Miguel Ángel White, Trenton M. Riveiro-Barciela, Mar Pocurull, Anna Morales-Arraez, Dalia Gómez, Alexandra Buti, Maria Lazarus, Jeffrey V. Late presentation of chronic HBV and HCV patients seeking first time specialist care in Spain: a 2-year registry review |
title | Late presentation of chronic HBV and HCV patients seeking first time specialist care in Spain: a 2-year registry review |
title_full | Late presentation of chronic HBV and HCV patients seeking first time specialist care in Spain: a 2-year registry review |
title_fullStr | Late presentation of chronic HBV and HCV patients seeking first time specialist care in Spain: a 2-year registry review |
title_full_unstemmed | Late presentation of chronic HBV and HCV patients seeking first time specialist care in Spain: a 2-year registry review |
title_short | Late presentation of chronic HBV and HCV patients seeking first time specialist care in Spain: a 2-year registry review |
title_sort | late presentation of chronic hbv and hcv patients seeking first time specialist care in spain: a 2-year registry review |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8683418/ https://www.ncbi.nlm.nih.gov/pubmed/34921156 http://dx.doi.org/10.1038/s41598-021-01885-0 |
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