Protective role of cytoplasmic p21Cip1/Waf1 in apoptosis of CDK4/6 inhibitor‐induced senescence in breast cancer cells

Inhibition of CDK4/6 slows the cell cycle and induces senescence in breast cancer cells. However, senescent cancer cells promote invasion and metastasis. Several drugs reportedly target senescent cells, including ABT‐263 (navitoclax). We examined the effects of the CDK4/6 inhibitor abemaciclib and A...

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Detalles Bibliográficos
Autores principales: Kartika, Irna D., Kotani, Hitoshi, Iida, Yuichi, Koyanagi, Akira, Tanino, Ryosuke, Harada, Mamoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8683524/
https://www.ncbi.nlm.nih.gov/pubmed/34761877
http://dx.doi.org/10.1002/cam4.4410

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8683524/
https://www.ncbi.nlm.nih.gov/pubmed/34761877
http://dx.doi.org/10.1002/cam4.4410

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