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Correlation between circulating tumor DNA and carcinoembryonic antigen levels in patients with metastatic colorectal cancer

BACKGROUND: Circulating tumor DNA (ctDNA) is a biomarker with potential to reflect comprehensive genomic information and overcome intratumor heterogeneity. In contrast, carcinoembryonic antigen (CEA) is a conventional tumor marker for predicting recurrence, survival, and chemotherapeutic efficacy in...

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Autores principales: Osumi, Hiroki, Shinozaki, Eiji, Ooki, Akira, Shimozaki, Keitaro, Kamiimabeppu, Daisaku, Nakayama, Izuma, Wakatsuki, Takeru, Ogura, Mariko, Takahari, Daisuke, Chin, Keisho, Yamaguchi, Kensei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8683548/
https://www.ncbi.nlm.nih.gov/pubmed/34821068
http://dx.doi.org/10.1002/cam4.4384
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author Osumi, Hiroki
Shinozaki, Eiji
Ooki, Akira
Shimozaki, Keitaro
Kamiimabeppu, Daisaku
Nakayama, Izuma
Wakatsuki, Takeru
Ogura, Mariko
Takahari, Daisuke
Chin, Keisho
Yamaguchi, Kensei
author_facet Osumi, Hiroki
Shinozaki, Eiji
Ooki, Akira
Shimozaki, Keitaro
Kamiimabeppu, Daisaku
Nakayama, Izuma
Wakatsuki, Takeru
Ogura, Mariko
Takahari, Daisuke
Chin, Keisho
Yamaguchi, Kensei
author_sort Osumi, Hiroki
collection PubMed
description BACKGROUND: Circulating tumor DNA (ctDNA) is a biomarker with potential to reflect comprehensive genomic information and overcome intratumor heterogeneity. In contrast, carcinoembryonic antigen (CEA) is a conventional tumor marker for predicting recurrence, survival, and chemotherapeutic efficacy in patients with metastatic colorectal cancer (mCRC). However, the relationship between them remains unclear. Here, the relationship between plasma ctDNA and CEA levels was evaluated to clarify the advantages and disadvantages of their clinical use. METHODS: A total of 110 patients with mCRC underwent chemotherapy were enrolled. Amplicon‐based plasma genomic profiling of 14 genes that are commonly mutated in CRC by next‐generation sequencing was compared to the CEA level and tumor diameter using Spearman’s correlation coefficient. RESULTS: The overall concordance rate between the ctDNA and CEA levels was 75.5% (83/110). The correlation coefficient between the ctDNA and CEA levels was lower in the group of patients without liver and lymph node metastases (r = 0.18, p = 0.44) than in the group of patients with liver metastasis (r = 0.48, p < 0.0001). Although the correlation coefficients between tumor diameter and both ctDNA and CEA levels were high in the group of patients with liver metastasis, only the CEA correlation coefficient was maintained in the group of patients without liver and lymph node metastases (r = 0.53, p = 0.01). The characteristics that influenced discordance were liver metastasis and the sum of tumor diameter. CONCLUSIONS: The status of ctDNA and CEA may not be consistent in patients with mCRC without liver metastasis or with a low tumor volume; both results should be considered when deciding a treatment strategy.
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spelling pubmed-86835482021-12-30 Correlation between circulating tumor DNA and carcinoembryonic antigen levels in patients with metastatic colorectal cancer Osumi, Hiroki Shinozaki, Eiji Ooki, Akira Shimozaki, Keitaro Kamiimabeppu, Daisaku Nakayama, Izuma Wakatsuki, Takeru Ogura, Mariko Takahari, Daisuke Chin, Keisho Yamaguchi, Kensei Cancer Med Clinical Cancer Research BACKGROUND: Circulating tumor DNA (ctDNA) is a biomarker with potential to reflect comprehensive genomic information and overcome intratumor heterogeneity. In contrast, carcinoembryonic antigen (CEA) is a conventional tumor marker for predicting recurrence, survival, and chemotherapeutic efficacy in patients with metastatic colorectal cancer (mCRC). However, the relationship between them remains unclear. Here, the relationship between plasma ctDNA and CEA levels was evaluated to clarify the advantages and disadvantages of their clinical use. METHODS: A total of 110 patients with mCRC underwent chemotherapy were enrolled. Amplicon‐based plasma genomic profiling of 14 genes that are commonly mutated in CRC by next‐generation sequencing was compared to the CEA level and tumor diameter using Spearman’s correlation coefficient. RESULTS: The overall concordance rate between the ctDNA and CEA levels was 75.5% (83/110). The correlation coefficient between the ctDNA and CEA levels was lower in the group of patients without liver and lymph node metastases (r = 0.18, p = 0.44) than in the group of patients with liver metastasis (r = 0.48, p < 0.0001). Although the correlation coefficients between tumor diameter and both ctDNA and CEA levels were high in the group of patients with liver metastasis, only the CEA correlation coefficient was maintained in the group of patients without liver and lymph node metastases (r = 0.53, p = 0.01). The characteristics that influenced discordance were liver metastasis and the sum of tumor diameter. CONCLUSIONS: The status of ctDNA and CEA may not be consistent in patients with mCRC without liver metastasis or with a low tumor volume; both results should be considered when deciding a treatment strategy. John Wiley and Sons Inc. 2021-11-24 /pmc/articles/PMC8683548/ /pubmed/34821068 http://dx.doi.org/10.1002/cam4.4384 Text en © 2021 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Cancer Research
Osumi, Hiroki
Shinozaki, Eiji
Ooki, Akira
Shimozaki, Keitaro
Kamiimabeppu, Daisaku
Nakayama, Izuma
Wakatsuki, Takeru
Ogura, Mariko
Takahari, Daisuke
Chin, Keisho
Yamaguchi, Kensei
Correlation between circulating tumor DNA and carcinoembryonic antigen levels in patients with metastatic colorectal cancer
title Correlation between circulating tumor DNA and carcinoembryonic antigen levels in patients with metastatic colorectal cancer
title_full Correlation between circulating tumor DNA and carcinoembryonic antigen levels in patients with metastatic colorectal cancer
title_fullStr Correlation between circulating tumor DNA and carcinoembryonic antigen levels in patients with metastatic colorectal cancer
title_full_unstemmed Correlation between circulating tumor DNA and carcinoembryonic antigen levels in patients with metastatic colorectal cancer
title_short Correlation between circulating tumor DNA and carcinoembryonic antigen levels in patients with metastatic colorectal cancer
title_sort correlation between circulating tumor dna and carcinoembryonic antigen levels in patients with metastatic colorectal cancer
topic Clinical Cancer Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8683548/
https://www.ncbi.nlm.nih.gov/pubmed/34821068
http://dx.doi.org/10.1002/cam4.4384
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