Schwannoma: A rare cause of false-positive 68Ga-PSMA PET/CT uptake in the evaluation of metastatic prostate cancer

PSMA expression occurs in epithelial cells in both normal and hyperplastic prostates. In adenocarcinoma, it is present in greater intensity, especially in the more aggressive ones. This made it possible to develop diagnostic tools with greater specificity for detecting prostate cancer metastases lik...

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Detalles Bibliográficos
Autores principales: Gualberto, Rodrigo J.C., Nister, Matheus, Castro, Pedro R. de, Arantes, Paulo B.O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8683589/
https://www.ncbi.nlm.nih.gov/pubmed/34976735
http://dx.doi.org/10.1016/j.eucr.2021.101974
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author Gualberto, Rodrigo J.C.
Nister, Matheus
Castro, Pedro R. de
Arantes, Paulo B.O.
author_facet Gualberto, Rodrigo J.C.
Nister, Matheus
Castro, Pedro R. de
Arantes, Paulo B.O.
author_sort Gualberto, Rodrigo J.C.
collection PubMed
description PSMA expression occurs in epithelial cells in both normal and hyperplastic prostates. In adenocarcinoma, it is present in greater intensity, especially in the more aggressive ones. This made it possible to develop diagnostic tools with greater specificity for detecting prostate cancer metastases like the 68Ga-PSMA PET/CT. Several benign neoplasms with increased marker uptake have been described in the literature. Such false-positives are usually associated with soft tissue injuries, abnormal vascular proliferation, neurogenic injuries, thymomas and adenomas. In the present work we present a case report that exemplifies the above.
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spelling pubmed-86835892021-12-30 Schwannoma: A rare cause of false-positive 68Ga-PSMA PET/CT uptake in the evaluation of metastatic prostate cancer Gualberto, Rodrigo J.C. Nister, Matheus Castro, Pedro R. de Arantes, Paulo B.O. Urol Case Rep Oncology PSMA expression occurs in epithelial cells in both normal and hyperplastic prostates. In adenocarcinoma, it is present in greater intensity, especially in the more aggressive ones. This made it possible to develop diagnostic tools with greater specificity for detecting prostate cancer metastases like the 68Ga-PSMA PET/CT. Several benign neoplasms with increased marker uptake have been described in the literature. Such false-positives are usually associated with soft tissue injuries, abnormal vascular proliferation, neurogenic injuries, thymomas and adenomas. In the present work we present a case report that exemplifies the above. Elsevier 2021-12-07 /pmc/articles/PMC8683589/ /pubmed/34976735 http://dx.doi.org/10.1016/j.eucr.2021.101974 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Oncology
Gualberto, Rodrigo J.C.
Nister, Matheus
Castro, Pedro R. de
Arantes, Paulo B.O.
Schwannoma: A rare cause of false-positive 68Ga-PSMA PET/CT uptake in the evaluation of metastatic prostate cancer
title Schwannoma: A rare cause of false-positive 68Ga-PSMA PET/CT uptake in the evaluation of metastatic prostate cancer
title_full Schwannoma: A rare cause of false-positive 68Ga-PSMA PET/CT uptake in the evaluation of metastatic prostate cancer
title_fullStr Schwannoma: A rare cause of false-positive 68Ga-PSMA PET/CT uptake in the evaluation of metastatic prostate cancer
title_full_unstemmed Schwannoma: A rare cause of false-positive 68Ga-PSMA PET/CT uptake in the evaluation of metastatic prostate cancer
title_short Schwannoma: A rare cause of false-positive 68Ga-PSMA PET/CT uptake in the evaluation of metastatic prostate cancer
title_sort schwannoma: a rare cause of false-positive 68ga-psma pet/ct uptake in the evaluation of metastatic prostate cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8683589/
https://www.ncbi.nlm.nih.gov/pubmed/34976735
http://dx.doi.org/10.1016/j.eucr.2021.101974
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