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Nuclear respiratory factor-1 negatively regulates TGF-β1 and attenuates pulmonary fibrosis

The preclinical model of bleomycin-induced lung fibrosis is useful to study mechanisms related to human pulmonary fibrosis. Using BLM in mice, we find low HO-1 expression. Although a unique Rhenium-CO-releasing molecule (ReCORM) up-regulates HO-1, NRF-1, CCN5, and SMAD7, it reduces TGFβ1, TGFβr1, co...

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Detalles Bibliográficos
Autores principales:	Suliman, Hagir B., Healy, Zachary, Zobi, Fabio, Kraft, Bryan D., Welty-Wolf, Karen, Smith, Joshua, Barkauskas, Christina, Piantadosi, Claude A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8683592/ https://www.ncbi.nlm.nih.gov/pubmed/34977500 http://dx.doi.org/10.1016/j.isci.2021.103535

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