Orthotopic T-cell receptor replacement in primary human T cells using CRISPR-Cas9-mediated homology-directed repair

Adoptive T cell therapy using T-cell receptor (TCR)-engineered T cells allows to redirect T cell specificity and to target any antigen of interest. Here, we apply advanced genetic engineering using clustered regularly interspaced short palindromic repeats (CRISPR)-associated protein 9 (Cas9) for sim...

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Detalles Bibliográficos
Autores principales: Moosmann, Carolin, Müller, Thomas R., Busch, Dirk H., Schober, Kilian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8683654/
https://www.ncbi.nlm.nih.gov/pubmed/34977677
http://dx.doi.org/10.1016/j.xpro.2021.101031

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