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Oral etoposide and zosuquidar bioavailability in rats: Effect of co-administration and in vitro-in vivo correlation of P-glycoprotein inhibition

P-glycoprotein inhibitors, like zosuquidar, have widely been used to study the role of P-glycoprotein in oral absorption. Still, systematic studies on the inhibitor dose-response relationship on intestinal drug permeation are lacking. In the present study, we investigated the effect of 0.79 nM-2.5 μ...

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Detalles Bibliográficos
Autores principales:	Nielsen, Rasmus Blaaholm, Holm, René, Pijpers, Ils, Snoeys, Jan, Nielsen, Ulla Gro, Nielsen, Carsten Uhd
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8683663/ https://www.ncbi.nlm.nih.gov/pubmed/34977557 http://dx.doi.org/10.1016/j.ijpx.2021.100089

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