In vivo pharmacokinetic study of remdesivir dry powder for inhalation in hamsters

Remdesivir dry powder for inhalation was previously developed using thin film freezing (TFF). A single-dose 24-h pharmacokinetic study in hamsters demonstrated that pulmonary delivery of TFF remdesivir can achieve plasma remdesivir and GS-441524 levels higher than the reported EC(50)s of both remdes...

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Detalles Bibliográficos
Autores principales: Sahakijpijarn, Sawittree, Moon, Chaeho, Warnken, Zachary N., Maier, Esther Y., DeVore, Jennie E., Christensen, Dale J., Koleng, John J., Williams, Robert O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8683664/
https://www.ncbi.nlm.nih.gov/pubmed/34977555
http://dx.doi.org/10.1016/j.ijpx.2021.100073

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